Acquisition-weighted MR Current Density Imaging (AW-MRCDI) improves sensitivity and spatial resolution

Cihan Göksu; L.G. Hanson; Frodi Gregersen; Klaus Scheffler; Axel Thielscher

Acquisition-weighted MR Current Density Imaging (AW-MRCDI) improves sensitivity and spatial resolution

Cihan Göksu, L.G. Hanson, Frodi Gregersen, Klaus Scheffler, Axel Thielscher

Abstract

Exact knowledge of currents flowing inside the human brain is important for several neuroscientific applications. MRCDI combines MR with externally injected weak currents, and uses measurements of the current-induced magnetic field to estimate spatial current distribution. The method’s accuracy highly depends on the sensitivity and spatial resolution of the field measurements. Here, we improve the currently most sensitive MRCDI method based on steady-state free precession free induction decay (SSFP-FID) by using an acquisition-weighted scheme (AW-MRCDI). We compared weighted and conventional schemes by phantom experiments. AW-MRCDI demonstrated 59% increase in sensitivity and significantly improved the spatial resolution.

Original language	English
Title of host publication	Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages	1
Publisher	The International Society for Magnetic Resonance in Medicine
Publication date	2020
Pages	1-1
Article number	3189
Publication status	Published - 2020
Event	ISMRM & SMRT Virtual Conference & Exhibition 2020 - Virtual conference Duration: 8 Aug 2020 → 14 Aug 2020 https://www.ismrm.org/20m/

Conference

Conference	ISMRM & SMRT Virtual Conference & Exhibition 2020
Location	Virtual conference
Period	08/08/2020 → 14/08/2020
Internet address	https://www.ismrm.org/20m/

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Göksu, C., Hanson, L. G., Gregersen, F., Scheffler, K., & Thielscher, A. (2020). Acquisition-weighted MR Current Density Imaging (AW-MRCDI) improves sensitivity and spatial resolution. In Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition (pp. 1-1). Article 3189 The International Society for Magnetic Resonance in Medicine. https://archive.ismrm.org/2020/3189.html

Acquisition-weighted MR Current Density Imaging (AW-MRCDI) improves sensitivity and spatial resolution. / Göksu, Cihan ; Hanson, L.G.; Gregersen, Frodi et al.
Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition. The International Society for Magnetic Resonance in Medicine, 2020. p. 1-1 3189.

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

Göksu, C , Hanson, LG , Gregersen, F, Scheffler, K & Thielscher, A 2020, Acquisition-weighted MR Current Density Imaging (AW-MRCDI) improves sensitivity and spatial resolution. in Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition., 3189, The International Society for Magnetic Resonance in Medicine, pp. 1-1, ISMRM & SMRT Virtual Conference & Exhibition 2020, 08/08/2020. <https://archive.ismrm.org/2020/3189.html>

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title = "Acquisition-weighted MR Current Density Imaging (AW-MRCDI) improves sensitivity and spatial resolution",

abstract = "Exact knowledge of currents flowing inside the human brain is important for several neuroscientific applications. MRCDI combines MR with externally injected weak currents, and uses measurements of the current-induced magnetic field to estimate spatial current distribution. The method{\textquoteright}s accuracy highly depends on the sensitivity and spatial resolution of the field measurements. Here, we improve the currently most sensitive MRCDI method based on steady-state free precession free induction decay (SSFP-FID) by using an acquisition-weighted scheme (AW-MRCDI). We compared weighted and conventional schemes by phantom experiments. AW-MRCDI demonstrated 59\% increase in sensitivity and significantly improved the spatial resolution.",

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year = "2020",

language = "English",

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booktitle = "Proceedings of the 2020 ISMRM \& SMRT Virtual Conference \& Exhibition",

publisher = "The International Society for Magnetic Resonance in Medicine",

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T1 - Acquisition-weighted MR Current Density Imaging (AW-MRCDI) improves sensitivity and spatial resolution

AU - Göksu, Cihan

AU - Hanson, L.G.

AU - Gregersen, Frodi

AU - Scheffler, Klaus

AU - Thielscher, Axel

PY - 2020

Y1 - 2020

N2 - Exact knowledge of currents flowing inside the human brain is important for several neuroscientific applications. MRCDI combines MR with externally injected weak currents, and uses measurements of the current-induced magnetic field to estimate spatial current distribution. The method’s accuracy highly depends on the sensitivity and spatial resolution of the field measurements. Here, we improve the currently most sensitive MRCDI method based on steady-state free precession free induction decay (SSFP-FID) by using an acquisition-weighted scheme (AW-MRCDI). We compared weighted and conventional schemes by phantom experiments. AW-MRCDI demonstrated 59% increase in sensitivity and significantly improved the spatial resolution.

AB - Exact knowledge of currents flowing inside the human brain is important for several neuroscientific applications. MRCDI combines MR with externally injected weak currents, and uses measurements of the current-induced magnetic field to estimate spatial current distribution. The method’s accuracy highly depends on the sensitivity and spatial resolution of the field measurements. Here, we improve the currently most sensitive MRCDI method based on steady-state free precession free induction decay (SSFP-FID) by using an acquisition-weighted scheme (AW-MRCDI). We compared weighted and conventional schemes by phantom experiments. AW-MRCDI demonstrated 59% increase in sensitivity and significantly improved the spatial resolution.

M3 - Conference abstract in proceedings

SP - 1

EP - 1

BT - Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition

PB - The International Society for Magnetic Resonance in Medicine

T2 - ISMRM & SMRT Virtual Conference & Exhibition 2020

Y2 - 8 August 2020 through 14 August 2020

ER -

Acquisition-weighted MR Current Density Imaging (AW-MRCDI) improves sensitivity and spatial resolution

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