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Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C

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  1. Reliable cell and tissue morphology-based diagnosis of endemic Burkitt lymphoma in resource-constrained settings in Ghana

    Research output: Contribution to journalJournal articleResearchpeer-review

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  3. Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG

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  4. Human Vδ1+ T Cells in the Immune Response to Plasmodium falciparum Infection

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Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1. The kinetics of acquisition of IgG to group B and C PfEMP1 proteins binding ICAM-1 is unclear and was studied here. Gene sequences encoding group B and C PfEMP1 with DBLβ domains known to bind ICAM-1 were used to identify additional binders. Levels of IgG specific for DBLβ domains from group A, B, and C PfEMP1 binding or not binding ICAM-1 were measured in plasma from Ghanaian children with or without malaria. Seven new ICAM-1-binding DBLβ domains from group B and C PfEMP1 were identified. Healthy children had higher levels of IgG specific for ICAM-1-binding DBLβ domains from group A than from groups B and C. However, the opposite pattern was found in children with malaria, particularly among young patients. Acquisition of IgG specific for DBLβ domains binding ICAM-1 differs between PfEMP1 groups.

Original languageEnglish
JournalInfection and Immunity
Volume87
Issue number10
ISSN0019-9567
DOIs
Publication statusPublished - Oct 2019

    Research areas

  • Antibodies, Protozoan/biosynthesis, Child, Child, Preschool, Erythrocytes/immunology, Female, Gene Expression, Ghana, Humans, Immunoglobulin G/biosynthesis, Infant, Intercellular Adhesion Molecule-1/genetics, Malaria, Cerebral/genetics, Malaria, Falciparum/genetics, Male, Plasmodium falciparum/immunology, Polymorphism, Genetic, Protein Binding, Protein Domains, Protozoan Proteins/classification, Seasons, Severity of Illness Index

ID: 59421092