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Acinar cystic transformation of the pancreas: Report of a case and a review of the literature

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@article{b10070d5e5174c9ca487e07de37e8944,
title = "Acinar cystic transformation of the pancreas: Report of a case and a review of the literature",
abstract = "Acinar cystic transformation (ACT) is a rare cystic lesion of the pancreas lately reclassified as a non-neoplastic entity. This is a presentation of a case of ACT and a review of the literature. A systematic PubMed search was conducted, yielding a result of 24 publications. Including our case report, 75 cases of ACT have been reported in the literature. The patients are mainly females with initial symptoms of abdominal pain. The cysts are primarily located in the head of the pancreas and are often multilocular on cross section and have a mean size of 53.2 mm. Microscopically, the cysts are lined by an acinar epithelium with abortive acinar formations. The cells are immunohistochemically positive in stains for trypsin, chymotrypsin and CK7. The Ki67-index is low; 1-2 %. No genetic alterations indicative of a neoplastic pathogenesis have been found. The mean follow up time is 37.4 months and no malignant transformation has been observed. A preoperative diagnosis is difficult to establish, but microbiopsies seem a promising tool. The indication for surgical intervention should be founded on the symptoms of the patients since no malignant transformation has ever been reported.",
keywords = "Acinar, Cyst, Cystadenoma, Neoplasm, Pancreas",
author = "Rift, {Charlotte Vestrup} and Hasselby, {Jane Preuss} and Hansen, {Carsten Paln{\ae}s} and Birgitte Federspiel",
note = "Copyright {\textcopyright} 2020 The Authors. Published by Elsevier GmbH.. All rights reserved.",
year = "2020",
month = jun,
doi = "10.1016/j.prp.2020.152928",
language = "English",
volume = "216",
pages = "152928",
journal = "Pathology Research and Practice",
issn = "0344-0338",
publisher = "Urban und Fischer Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - Acinar cystic transformation of the pancreas

T2 - Report of a case and a review of the literature

AU - Rift, Charlotte Vestrup

AU - Hasselby, Jane Preuss

AU - Hansen, Carsten Palnæs

AU - Federspiel, Birgitte

N1 - Copyright © 2020 The Authors. Published by Elsevier GmbH.. All rights reserved.

PY - 2020/6

Y1 - 2020/6

N2 - Acinar cystic transformation (ACT) is a rare cystic lesion of the pancreas lately reclassified as a non-neoplastic entity. This is a presentation of a case of ACT and a review of the literature. A systematic PubMed search was conducted, yielding a result of 24 publications. Including our case report, 75 cases of ACT have been reported in the literature. The patients are mainly females with initial symptoms of abdominal pain. The cysts are primarily located in the head of the pancreas and are often multilocular on cross section and have a mean size of 53.2 mm. Microscopically, the cysts are lined by an acinar epithelium with abortive acinar formations. The cells are immunohistochemically positive in stains for trypsin, chymotrypsin and CK7. The Ki67-index is low; 1-2 %. No genetic alterations indicative of a neoplastic pathogenesis have been found. The mean follow up time is 37.4 months and no malignant transformation has been observed. A preoperative diagnosis is difficult to establish, but microbiopsies seem a promising tool. The indication for surgical intervention should be founded on the symptoms of the patients since no malignant transformation has ever been reported.

AB - Acinar cystic transformation (ACT) is a rare cystic lesion of the pancreas lately reclassified as a non-neoplastic entity. This is a presentation of a case of ACT and a review of the literature. A systematic PubMed search was conducted, yielding a result of 24 publications. Including our case report, 75 cases of ACT have been reported in the literature. The patients are mainly females with initial symptoms of abdominal pain. The cysts are primarily located in the head of the pancreas and are often multilocular on cross section and have a mean size of 53.2 mm. Microscopically, the cysts are lined by an acinar epithelium with abortive acinar formations. The cells are immunohistochemically positive in stains for trypsin, chymotrypsin and CK7. The Ki67-index is low; 1-2 %. No genetic alterations indicative of a neoplastic pathogenesis have been found. The mean follow up time is 37.4 months and no malignant transformation has been observed. A preoperative diagnosis is difficult to establish, but microbiopsies seem a promising tool. The indication for surgical intervention should be founded on the symptoms of the patients since no malignant transformation has ever been reported.

KW - Acinar

KW - Cyst

KW - Cystadenoma

KW - Neoplasm

KW - Pancreas

UR - http://www.scopus.com/inward/record.url?scp=85081978550&partnerID=8YFLogxK

U2 - 10.1016/j.prp.2020.152928

DO - 10.1016/j.prp.2020.152928

M3 - Review

C2 - 32204924

VL - 216

SP - 152928

JO - Pathology Research and Practice

JF - Pathology Research and Practice

SN - 0344-0338

IS - 6

M1 - 152928

ER -

ID: 60013884