ACE-inhibitor induced angio-oedema treated with complement C1-inhibitor concentrate

Eva Rye Rasmussen, Anette Bygum

22 Citations (Scopus)


ACE-inhibitor is an antihypertensive drug which is increasingly used to treat a wide range of medical conditions. A known adverse reaction is angio-oedema of the head and neck, which can become fatal when the upper airway is involved, causing asphyxia. We present a Caucasian man, who developed severe angio-oedema of the tongue and floor of the mouth. He was successfully treated with complement C1-concentrate causing the swelling to regress within 20 min. This treatment option can be an effective alternative to bradykinin antagonists, which might not be available in the emergency room, or more invasive measures like intubation or emergency airway puncture.

Original languageEnglish
JournalBMJ Case Reports
Publication statusPublished - 4 Oct 2013
Externally publishedYes


  • Angioedema
  • Angiotensin-Converting Enzyme Inhibitors
  • Anti-Inflammatory Agents, Non-Steroidal
  • Bradykinin
  • Complement C1
  • Diagnosis, Differential
  • Humans
  • Male
  • Middle Aged
  • Palate, Soft
  • Tongue
  • Case Reports
  • Journal Article


Dive into the research topics of 'ACE-inhibitor induced angio-oedema treated with complement C1-inhibitor concentrate'. Together they form a unique fingerprint.

Cite this