Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Urowitz, MB, Gladman, DD, Farewell, V, Su, J, Romero-Diaz, J, Bae, S-C, Fortin, PR, Sanchez-Guerrero, J, Clarke, AE, Bernatsky, S, Gordon, C, Hanly, JG, Wallace, DJ, Isenberg, DA, Rahman, A, Merrill, JT, Ginzler, E, Alarcón, GS, Chatham, WW, Petri, MA, Bruce, IN, Khamashta, MA, Aranow, C, Dooley, MA, Manzi, S, Ramsey-Goldman, R, Nived, O, Jönsen, A, Steinsson, K, Zoma, AA, Ruiz-Irastorza, G, Lim, SS, Kalunian, KC, Ỉnanç, M, van Vollenhoven, R, Ramos-Casals, M, Kamen, DL, Jacobsen, S, Peschken, CA, Askanase, A & Stoll, T 2020, 'Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort', Arthritis and Rheumatology, vol. 72, no. 10, pp. 1734-1740. https://doi.org/10.1002/art.41392

APA

Urowitz, M. B., Gladman, D. D., Farewell, V., Su, J., Romero-Diaz, J., Bae, S-C., Fortin, P. R., Sanchez-Guerrero, J., Clarke, A. E., Bernatsky, S., Gordon, C., Hanly, J. G., Wallace, D. J., Isenberg, D. A., Rahman, A., Merrill, J. T., Ginzler, E., Alarcón, G. S., Chatham, W. W., ... Stoll, T. (2020). Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort. Arthritis and Rheumatology, 72(10), 1734-1740. https://doi.org/10.1002/art.41392

CBE

Urowitz MB, Gladman DD, Farewell V, Su J, Romero-Diaz J, Bae S-C, Fortin PR, Sanchez-Guerrero J, Clarke AE, Bernatsky S, Gordon C, Hanly JG, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Ginzler E, Alarcón GS, Chatham WW, Petri MA, Bruce IN, Khamashta MA, Aranow C, Dooley MA, Manzi S, Ramsey-Goldman R, Nived O, Jönsen A, Steinsson K, Zoma AA, Ruiz-Irastorza G, Lim SS, Kalunian KC, Ỉnanç M, van Vollenhoven R, Ramos-Casals M, Kamen DL, Jacobsen S, Peschken CA, Askanase A, Stoll T. 2020. Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort. Arthritis and Rheumatology. 72(10):1734-1740. https://doi.org/10.1002/art.41392

MLA

Vancouver

Author

Urowitz, Murray B ; Gladman, Dafna D ; Farewell, Vernon ; Su, Jiandong ; Romero-Diaz, Juanita ; Bae, Sang-Cheol ; Fortin, Paul R ; Sanchez-Guerrero, Jorge ; Clarke, Ann Elaine ; Bernatsky, Sasha ; Gordon, Caroline ; Hanly, John G ; Wallace, Daniel J ; Isenberg, David A ; Rahman, Anisur ; Merrill, Joan T ; Ginzler, Ellen ; Alarcón, Graciela S ; Chatham, W Winn ; Petri, Michelle A ; Bruce, Ian N ; Khamashta, Munther A ; Aranow, Cynthia ; Dooley, Mary Anne ; Manzi, Susan ; Ramsey-Goldman, Rosalind ; Nived, Ola ; Jönsen, Andreas ; Steinsson, Kristján ; Zoma, Asad A ; Ruiz-Irastorza, Guillermo ; Lim, S Sam ; Kalunian, Kenneth C ; Ỉnanç, Murat ; van Vollenhoven, Ronald ; Ramos-Casals, Manuel ; Kamen, Diane L ; Jacobsen, Soren ; Peschken, Christine A ; Askanase, Anca ; Stoll, Thomas. / Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort. In: Arthritis and Rheumatology. 2020 ; Vol. 72, No. 10. pp. 1734-1740.

Bibtex

@article{c7f0a25711a64c9496c2e67a382435fa,
title = "Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort",
abstract = "Objective: In previous studies, atherosclerotic vascular events (AVEs) were shown to occur in ~10% of patients with systemic lupus erythematosus (SLE). We undertook this study to investigate the annual occurrence and potential risk factors for AVEs in a multinational, multiethnic inception cohort of patients with SLE. Methods: A large 33-center cohort of SLE patients was followed up yearly between 1999 and 2017. AVEs were attributed to atherosclerosis based on SLE being inactive at the time of the AVE as well as typical atherosclerotic changes observed on imaging or pathology reports and/or evidence of atherosclerosis elsewhere. Analyses included descriptive statistics, rate of AVEs per 1,000 patient-years, and univariable and multivariable relative risk regression models. Results: Of the 1,848 patients enrolled in the cohort, 1,710 had ≥1 follow-up visit after enrollment, for a total of 13,666 patient-years. Of these 1,710 patients, 3.6% had ≥1 AVEs attributed to atherosclerosis, for an event rate of 4.6 per 1,000 patient-years. In multivariable analyses, lower AVE rates were associated with antimalarial treatment (hazard ratio [HR] 0.54 [95% confidence interval (95% CI) 0.32–0.91]), while higher AVE rates were associated with any prior vascular event (HR 4.00 [95% CI 1.55–10.30]) and a body mass index of >40 kg/m 2 (HR 2.74 [95% CI 1.04–7.18]). A prior AVE increased the risk of subsequent AVEs (HR 5.42 [95% CI 3.17–9.27], P < 0.001). Conclusion: The prevalence of AVEs and the rate of AVE accrual demonstrated in the present study is much lower than that seen in previously published data. This may be related to better control of both the disease activity and classic risk factors. ",
keywords = "Adult, Atherosclerosis/epidemiology, Comorbidity, Female, Humans, Incidence, Lupus Erythematosus, Systemic/epidemiology, Male, Middle Aged, Prevalence, Risk, Young Adult",
author = "Urowitz, {Murray B} and Gladman, {Dafna D} and Vernon Farewell and Jiandong Su and Juanita Romero-Diaz and Sang-Cheol Bae and Fortin, {Paul R} and Jorge Sanchez-Guerrero and Clarke, {Ann Elaine} and Sasha Bernatsky and Caroline Gordon and Hanly, {John G} and Wallace, {Daniel J} and Isenberg, {David A} and Anisur Rahman and Merrill, {Joan T} and Ellen Ginzler and Alarc{\'o}n, {Graciela S} and Chatham, {W Winn} and Petri, {Michelle A} and Bruce, {Ian N} and Khamashta, {Munther A} and Cynthia Aranow and Dooley, {Mary Anne} and Susan Manzi and Rosalind Ramsey-Goldman and Ola Nived and Andreas J{\"o}nsen and Kristj{\'a}n Steinsson and Zoma, {Asad A} and Guillermo Ruiz-Irastorza and Lim, {S Sam} and Kalunian, {Kenneth C} and Murat Ỉnan{\c c} and {van Vollenhoven}, Ronald and Manuel Ramos-Casals and Kamen, {Diane L} and Soren Jacobsen and Peschken, {Christine A} and Anca Askanase and Thomas Stoll",
note = "{\textcopyright} 2020, American College of Rheumatology.",
year = "2020",
month = oct,
doi = "10.1002/art.41392",
language = "English",
volume = "72",
pages = "1734--1740",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "10",

}

RIS

TY - JOUR

T1 - Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort

AU - Urowitz, Murray B

AU - Gladman, Dafna D

AU - Farewell, Vernon

AU - Su, Jiandong

AU - Romero-Diaz, Juanita

AU - Bae, Sang-Cheol

AU - Fortin, Paul R

AU - Sanchez-Guerrero, Jorge

AU - Clarke, Ann Elaine

AU - Bernatsky, Sasha

AU - Gordon, Caroline

AU - Hanly, John G

AU - Wallace, Daniel J

AU - Isenberg, David A

AU - Rahman, Anisur

AU - Merrill, Joan T

AU - Ginzler, Ellen

AU - Alarcón, Graciela S

AU - Chatham, W Winn

AU - Petri, Michelle A

AU - Bruce, Ian N

AU - Khamashta, Munther A

AU - Aranow, Cynthia

AU - Dooley, Mary Anne

AU - Manzi, Susan

AU - Ramsey-Goldman, Rosalind

AU - Nived, Ola

AU - Jönsen, Andreas

AU - Steinsson, Kristján

AU - Zoma, Asad A

AU - Ruiz-Irastorza, Guillermo

AU - Lim, S Sam

AU - Kalunian, Kenneth C

AU - Ỉnanç, Murat

AU - van Vollenhoven, Ronald

AU - Ramos-Casals, Manuel

AU - Kamen, Diane L

AU - Jacobsen, Soren

AU - Peschken, Christine A

AU - Askanase, Anca

AU - Stoll, Thomas

N1 - © 2020, American College of Rheumatology.

PY - 2020/10

Y1 - 2020/10

N2 - Objective: In previous studies, atherosclerotic vascular events (AVEs) were shown to occur in ~10% of patients with systemic lupus erythematosus (SLE). We undertook this study to investigate the annual occurrence and potential risk factors for AVEs in a multinational, multiethnic inception cohort of patients with SLE. Methods: A large 33-center cohort of SLE patients was followed up yearly between 1999 and 2017. AVEs were attributed to atherosclerosis based on SLE being inactive at the time of the AVE as well as typical atherosclerotic changes observed on imaging or pathology reports and/or evidence of atherosclerosis elsewhere. Analyses included descriptive statistics, rate of AVEs per 1,000 patient-years, and univariable and multivariable relative risk regression models. Results: Of the 1,848 patients enrolled in the cohort, 1,710 had ≥1 follow-up visit after enrollment, for a total of 13,666 patient-years. Of these 1,710 patients, 3.6% had ≥1 AVEs attributed to atherosclerosis, for an event rate of 4.6 per 1,000 patient-years. In multivariable analyses, lower AVE rates were associated with antimalarial treatment (hazard ratio [HR] 0.54 [95% confidence interval (95% CI) 0.32–0.91]), while higher AVE rates were associated with any prior vascular event (HR 4.00 [95% CI 1.55–10.30]) and a body mass index of >40 kg/m 2 (HR 2.74 [95% CI 1.04–7.18]). A prior AVE increased the risk of subsequent AVEs (HR 5.42 [95% CI 3.17–9.27], P < 0.001). Conclusion: The prevalence of AVEs and the rate of AVE accrual demonstrated in the present study is much lower than that seen in previously published data. This may be related to better control of both the disease activity and classic risk factors.

AB - Objective: In previous studies, atherosclerotic vascular events (AVEs) were shown to occur in ~10% of patients with systemic lupus erythematosus (SLE). We undertook this study to investigate the annual occurrence and potential risk factors for AVEs in a multinational, multiethnic inception cohort of patients with SLE. Methods: A large 33-center cohort of SLE patients was followed up yearly between 1999 and 2017. AVEs were attributed to atherosclerosis based on SLE being inactive at the time of the AVE as well as typical atherosclerotic changes observed on imaging or pathology reports and/or evidence of atherosclerosis elsewhere. Analyses included descriptive statistics, rate of AVEs per 1,000 patient-years, and univariable and multivariable relative risk regression models. Results: Of the 1,848 patients enrolled in the cohort, 1,710 had ≥1 follow-up visit after enrollment, for a total of 13,666 patient-years. Of these 1,710 patients, 3.6% had ≥1 AVEs attributed to atherosclerosis, for an event rate of 4.6 per 1,000 patient-years. In multivariable analyses, lower AVE rates were associated with antimalarial treatment (hazard ratio [HR] 0.54 [95% confidence interval (95% CI) 0.32–0.91]), while higher AVE rates were associated with any prior vascular event (HR 4.00 [95% CI 1.55–10.30]) and a body mass index of >40 kg/m 2 (HR 2.74 [95% CI 1.04–7.18]). A prior AVE increased the risk of subsequent AVEs (HR 5.42 [95% CI 3.17–9.27], P < 0.001). Conclusion: The prevalence of AVEs and the rate of AVE accrual demonstrated in the present study is much lower than that seen in previously published data. This may be related to better control of both the disease activity and classic risk factors.

KW - Adult

KW - Atherosclerosis/epidemiology

KW - Comorbidity

KW - Female

KW - Humans

KW - Incidence

KW - Lupus Erythematosus, Systemic/epidemiology

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Risk

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85089782157&partnerID=8YFLogxK

U2 - 10.1002/art.41392

DO - 10.1002/art.41392

M3 - Journal article

C2 - 32515554

VL - 72

SP - 1734

EP - 1740

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 10

ER -

ID: 61876165