Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations

O Andersen, M K Nielsen, P B Eriksen, M Fenger, P J Knudsen

Abstract

Ten healthy volunteers received two sustained-release preparations as a single and multiple dose regimen in an open crossover study. Plasma theophylline concentrations were measured by an enzyme immunoassay. The limited fluctuation of the theophylline levels at steady state, with twice daily administration, clearly demonstrated the marked sustained release properties of both preparations. Results indicate similar properties for the two preparations. Significant correlations between the single dose period and steady state were found for Cmax and AUC (r = 0.76 and 0.87, respectively) with one formulation, whereas this was not the case for the other (r = 0.27 and 0.49). The daily dose necessary to keep the plasma concentration within the therapeutic range of 55-110 mumole/liter varied from 7.9 to 22.9 mg/kg. Only mild side effects were recorded, but they were not correlated to the plasma theophylline concentration.

Original languageEnglish
JournalJournal of pharmaceutical sciences
Volume72
Issue number2
Pages (from-to)158-61
Number of pages4
ISSN0022-3549
DOIs
Publication statusPublished - Feb 1983

Keywords

  • Absorption
  • Adult
  • Delayed-Action Preparations
  • Female
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Theophylline/administration & dosage
  • Time Factors

Fingerprint

Dive into the research topics of 'Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations'. Together they form a unique fingerprint.

Cite this