Absolute and attributable risk of venous thromboembolism in women on combined cyproterone acetate and ethinylestradiol

Øjvind Lidegaard

doi:10.1016/s1701-2163(16)31016-7

Absolute and attributable risk of venous thromboembolism in women on combined cyproterone acetate and ethinylestradiol

11 Citations (Scopus)

Abstract

OBJECTIVE: To achieve absolute risk estimates of venous thromboembolism (VTE) among women on cyproterone acetate plus ethinylestradiol (CPA/EE), and among women on combined oral contraceptives (COCs).

METHODS: From the Danish National Register of Patients (NRP), 1996 to 1998, the records of 1.1 million Danish women, ages 15 to 44 years, were searched for evidence of VTE. COC use was ascertained through mailed questionnaires. Sales statistics of COCs and CPA/EE were provided through Danish Drug Statistics.

RESULTS: During the time frame of the study, 330 women were found to have had VTE while on COCs. Of these women, 67 were on levonorgestrel-containing COCs. Eleven were on CPA/EE. The corresponding absolute risk of VTE was 3.4 (range, 3.1-3.8) per 10 000 women years among the women on COCs, 4.2 (range, 3.2-5.2) per 10 000 women years among women on levonorgestrel-containing COCs, and 3.1 (range, 1.3-4.9) per 10 000 women years among the women on CPA/EE.

CONCLUSION: Our results suggest the absolute risk of VTE among Danish women on COCs is similar to that among women taking CPA/EE.

Original language	English
Journal	Journal of Obstetrics and Gynaecology Research
Volume	25
Issue number	7
Pages (from-to)	575-7
Number of pages	3
ISSN	1701-2163
DOIs	https://doi.org/10.1016/s1701-2163(16)31016-7
Publication status	Published - Jul 2003
Externally published	Yes

Keywords

Adolescent
Adult
Contraceptives, Oral, Combined/administration & dosage
Cyproterone Acetate/administration & dosage
Denmark/epidemiology
Epidemiologic Studies
Ethinyl Estradiol/administration & dosage
Female
Humans
Risk Assessment
Risk Factors
Thromboembolism/chemically induced
Venous Thrombosis/chemically induced

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10.1016/s1701-2163(16)31016-7

Cite this

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title = "Absolute and attributable risk of venous thromboembolism in women on combined cyproterone acetate and ethinylestradiol",

abstract = "OBJECTIVE: To achieve absolute risk estimates of venous thromboembolism (VTE) among women on cyproterone acetate plus ethinylestradiol (CPA/EE), and among women on combined oral contraceptives (COCs).METHODS: From the Danish National Register of Patients (NRP), 1996 to 1998, the records of 1.1 million Danish women, ages 15 to 44 years, were searched for evidence of VTE. COC use was ascertained through mailed questionnaires. Sales statistics of COCs and CPA/EE were provided through Danish Drug Statistics.RESULTS: During the time frame of the study, 330 women were found to have had VTE while on COCs. Of these women, 67 were on levonorgestrel-containing COCs. Eleven were on CPA/EE. The corresponding absolute risk of VTE was 3.4 (range, 3.1-3.8) per 10 000 women years among the women on COCs, 4.2 (range, 3.2-5.2) per 10 000 women years among women on levonorgestrel-containing COCs, and 3.1 (range, 1.3-4.9) per 10 000 women years among the women on CPA/EE.CONCLUSION: Our results suggest the absolute risk of VTE among Danish women on COCs is similar to that among women taking CPA/EE.",

keywords = "Adolescent, Adult, Contraceptives, Oral, Combined/administration \& dosage, Cyproterone Acetate/administration \& dosage, Denmark/epidemiology, Epidemiologic Studies, Ethinyl Estradiol/administration \& dosage, Female, Humans, Risk Assessment, Risk Factors, Thromboembolism/chemically induced, Venous Thrombosis/chemically induced",

author = "{\O}jvind Lidegaard",

year = "2003",

month = jul,

doi = "10.1016/s1701-2163(16)31016-7",

language = "English",

volume = "25",

pages = "575--7",

journal = "Journal of Obstetrics and Gynaecology Research",

issn = "1701-2163",

publisher = "John Wiley and Sons Inc.",

number = "7",

}

TY - JOUR

T1 - Absolute and attributable risk of venous thromboembolism in women on combined cyproterone acetate and ethinylestradiol

AU - Lidegaard, Øjvind

PY - 2003/7

Y1 - 2003/7

N2 - OBJECTIVE: To achieve absolute risk estimates of venous thromboembolism (VTE) among women on cyproterone acetate plus ethinylestradiol (CPA/EE), and among women on combined oral contraceptives (COCs).METHODS: From the Danish National Register of Patients (NRP), 1996 to 1998, the records of 1.1 million Danish women, ages 15 to 44 years, were searched for evidence of VTE. COC use was ascertained through mailed questionnaires. Sales statistics of COCs and CPA/EE were provided through Danish Drug Statistics.RESULTS: During the time frame of the study, 330 women were found to have had VTE while on COCs. Of these women, 67 were on levonorgestrel-containing COCs. Eleven were on CPA/EE. The corresponding absolute risk of VTE was 3.4 (range, 3.1-3.8) per 10 000 women years among the women on COCs, 4.2 (range, 3.2-5.2) per 10 000 women years among women on levonorgestrel-containing COCs, and 3.1 (range, 1.3-4.9) per 10 000 women years among the women on CPA/EE.CONCLUSION: Our results suggest the absolute risk of VTE among Danish women on COCs is similar to that among women taking CPA/EE.

AB - OBJECTIVE: To achieve absolute risk estimates of venous thromboembolism (VTE) among women on cyproterone acetate plus ethinylestradiol (CPA/EE), and among women on combined oral contraceptives (COCs).METHODS: From the Danish National Register of Patients (NRP), 1996 to 1998, the records of 1.1 million Danish women, ages 15 to 44 years, were searched for evidence of VTE. COC use was ascertained through mailed questionnaires. Sales statistics of COCs and CPA/EE were provided through Danish Drug Statistics.RESULTS: During the time frame of the study, 330 women were found to have had VTE while on COCs. Of these women, 67 were on levonorgestrel-containing COCs. Eleven were on CPA/EE. The corresponding absolute risk of VTE was 3.4 (range, 3.1-3.8) per 10 000 women years among the women on COCs, 4.2 (range, 3.2-5.2) per 10 000 women years among women on levonorgestrel-containing COCs, and 3.1 (range, 1.3-4.9) per 10 000 women years among the women on CPA/EE.CONCLUSION: Our results suggest the absolute risk of VTE among Danish women on COCs is similar to that among women taking CPA/EE.

KW - Adolescent

KW - Adult

KW - Contraceptives, Oral, Combined/administration & dosage

KW - Cyproterone Acetate/administration & dosage

KW - Denmark/epidemiology

KW - Epidemiologic Studies

KW - Ethinyl Estradiol/administration & dosage

KW - Female

KW - Humans

KW - Risk Assessment

KW - Risk Factors

KW - Thromboembolism/chemically induced

KW - Venous Thrombosis/chemically induced

UR - https://www.scopus.com/pages/publications/0141722307

U2 - 10.1016/s1701-2163(16)31016-7

DO - 10.1016/s1701-2163(16)31016-7

M3 - Journal article

C2 - 12851669

SN - 1701-2163

VL - 25

SP - 575

EP - 577

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

IS - 7

ER -

Absolute and attributable risk of venous thromboembolism in women on combined cyproterone acetate and ethinylestradiol

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Keywords

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