Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Body mass index in young men and risk of inflammatory bowel disease through adult life: A population-based Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Collagen turnover profiles in chronic kidney disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Development and Interlaboratory Validation of Two Fast UPLC-MS-MS Methods Determining Urinary Bisphenols, Parabens and Phthalates

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Tracing the origin of adult intestinal stem cells

    Research output: Contribution to journalLetterResearchpeer-review

  3. Characterization of Human Adrenal Steroidogenesis during Fetal Development

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Anne-Louise Gannon
  • Laura O'Hara
  • J Ian Mason
  • Diane Rebourcet
  • Sarah Smith
  • Adriana Traveres
  • Carlos Jose Alcaide-Corral
  • Hanne Frederiksen
  • Anne Jørgensen
  • Laura Milne
  • Rod T Mitchell
  • Lee B Smith
View graph of relations

The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis results in sustained elevated levels of glucocorticoids which impair neuronal function and can ultimately result in a psychiatric disorder. Studies investigating Glucocorticoid Receptor (GR/NR3C1) in the brain have primarily focused on the forebrain, however in recent years, the hindbrain has become a region of interest for research into the development of anxiety and depression, though the role of GR signalling in the hindbrain remains poorly characterised. To determine the role of glucocorticoid signalling in the hindbrain we have developed a novel mouse model that specifically ablates hindbrain GR to ascertain its role in behaviour, HPA-axis regulation and adrenal structure. Our study highlights that ablation of GR in the hindbrain results in excessive barbering, obsessive compulsive digging and lack of cage exploration. These mice also develop kyphosis, elevated circulating corticosterone and severe adrenal cortex disruption. Together, this data demonstrates a role for hindbrain GR signalling in regulating stress-related behaviour and identifies a novel mouse model to allow further investigation into the pathways impacting stress and anxiety.

Original languageEnglish
JournalScientific Reports
Volume9
Issue number1
Pages (from-to)3250
ISSN2045-2322
DOIs
Publication statusPublished - 1 Mar 2019

ID: 56741688