Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Intestinal sensing and handling of dietary lipids in gastric bypass-operated patients and matched controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Body mass index trajectories in early childhood in relation to cardiometabolic risk profile and body composition at 5 years of age

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A prospective study of artificially sweetened beverage intake and cardiometabolic health among women at high risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Describing the fecal metabolome in cryogenically collected samples from healthy participants

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Anna Viitasalo
  • Theresia M Schnurr
  • Niina Pitkänen
  • Mette Hollensted
  • Tenna R H Nielsen
  • Katja Pahkala
  • Mustafa Atalay
  • Mads V Lind
  • Sami Heikkinen
  • Christine Frithioff-Bøjsøe
  • Cilius E Fonvig
  • Niels Grarup
  • Mika Kähönen
  • Germán D Carrasquilla
  • Anni Larnkjaer
  • Oluf Pedersen
  • Kim F Michaelsen
  • Timo A Lakka
  • Jens-Christian Holm
  • Terho Lehtimäki
  • Olli Raitakari
  • Torben Hansen
  • Tuomas O Kilpeläinen
View graph of relations

BACKGROUND: Mendelian randomization studies in adults suggest that abdominal adiposity is causally associated with increased risk of type 2 diabetes and coronary artery disease in adults, but its causal effect on cardiometabolic risk in children remains unclear.

OBJECTIVE: We aimed to study the causal relation of abdominal adiposity with cardiometabolic risk factors in children by applying Mendelian randomization.

METHODS: We constructed a genetic risk score (GRS) using variants previously associated with waist-to-hip ratio adjusted for BMI (WHRadjBMI) and examined its associations with cardiometabolic factors by linear regression and Mendelian randomization in a meta-analysis of 6 cohorts, including 9895 European children and adolescents aged 3-17 y.

RESULTS: WHRadjBMI GRS was associated with higher WHRadjBMI (β = 0.021 SD/allele; 95% CI: 0.016, 0.026 SD/allele; P = 3 × 10-15) and with unfavorable concentrations of blood lipids (higher LDL cholesterol: β = 0.006 SD/allele; 95% CI: 0.001, 0.011 SD/allele; P = 0.025; lower HDL cholesterol: β = -0.007 SD/allele; 95% CI: -0.012, -0.002 SD/allele; P = 0.009; higher triglycerides: β = 0.007 SD/allele; 95% CI: 0.002, 0.012 SD/allele; P = 0.006). No differences were detected between prepubertal and pubertal/postpubertal children. The WHRadjBMI GRS had a stronger association with fasting insulin in children and adolescents with overweight/obesity (β = 0.016 SD/allele; 95% CI: 0.001, 0.032 SD/allele; P = 0.037) than in those with normal weight (β = -0.002 SD/allele; 95% CI: -0.010, 0.006 SD/allele; P = 0.605) (P for difference = 0.034). In a 2-stage least-squares regression analysis, each genetically instrumented 1-SD increase in WHRadjBMI increased circulating triglycerides by 0.17 mmol/L (0.35 SD, P = 0.040), suggesting that the relation between abdominal adiposity and circulating triglycerides may be causal.

CONCLUSIONS: Abdominal adiposity may have a causal, unfavorable effect on plasma triglycerides and potentially other cardiometabolic risk factors starting in childhood. The results highlight the importance of early weight management through healthy dietary habits and physically active lifestyle among children with a tendency for abdominal adiposity.

Original languageEnglish
JournalThe American journal of clinical nutrition
Volume110
Issue number5
Pages (from-to)1079-1087
Number of pages9
ISSN0002-9165
DOIs
Publication statusPublished - 1 Nov 2019

    Research areas

  • abdominal adiposity, ALSPAC, cardiometabolic risk, cardiovascular disease risk, children, Mendelian randomization, meta-analysis, waist-to-hip ratio

ID: 57934017