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A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk

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Harvard

Adel Fahmideh, M, Lavebratt, C, Tettamanti, G, Schüz, J, Röösli, M, Kjaerheim, K, Grotzer, MA, Johansen, C, Kuehni, CE, Lannering, B, Schmidt, LS, Darabi, H & Feychting, M 2019, 'A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk' Scientific Reports, vol. 9, 18142. https://doi.org/10.1038/s41598-019-54701-1

APA

Adel Fahmideh, M., Lavebratt, C., Tettamanti, G., Schüz, J., Röösli, M., Kjaerheim, K., ... Feychting, M. (2019). A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk. Scientific Reports, 9, [18142]. https://doi.org/10.1038/s41598-019-54701-1

CBE

Adel Fahmideh M, Lavebratt C, Tettamanti G, Schüz J, Röösli M, Kjaerheim K, Grotzer MA, Johansen C, Kuehni CE, Lannering B, Schmidt LS, Darabi H, Feychting M. 2019. A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk. Scientific Reports. 9. https://doi.org/10.1038/s41598-019-54701-1

MLA

Vancouver

Author

Adel Fahmideh, Maral ; Lavebratt, Catharina ; Tettamanti, Giorgio ; Schüz, Joachim ; Röösli, Martin ; Kjaerheim, Kristina ; Grotzer, Michael A ; Johansen, Christoffer ; Kuehni, Claudia E ; Lannering, Birgitta ; Schmidt, Lisbeth S ; Darabi, Hatef ; Feychting, Maria. / A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk. In: Scientific Reports. 2019 ; Vol. 9.

Bibtex

@article{af7f3ccf60d140cdb20ca781f19cbc8d,
title = "A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk",
abstract = "Genetic risk score (GRS) is used to demonstrate the genetic variants contributing to the polygenic architecture of complex diseases. By using a GRS, we have investigated the additive impact of the known adult glioma susceptibility loci on the pediatric brain tumor (PBT) risk and assessed the proportion of PBT heritability attributable to these susceptibility loci. A GRS was generated for PBTs based on the alleles and associated effect sizes derived from a previously published genome-wide association study on adult glioma. The GRS was calculated in CEFALO, a population-based case-control study of brain tumors in children and adolescents including saliva DNA of 245 cases and 489 controls. The unconditional logistic regression model was used to investigate the association between standardized GRS and risk of PBTs. To measure the variance explained by the effect of GRS, Nagelkerke pseudo-R2 was calculated. The GRS for adult brain tumors was associated with an increased risk of PBTs (OR 1.25 [95{\%} CI 1.06-1.49], p = 0.009) and 0.3{\%} of the variance in PBTs could be explained by the effect of GRS on the liability scale. This study provides evidence that heritable risks of PBTs are in-part attributable to some common genetic variants associated with adult glioma.",
author = "{Adel Fahmideh}, Maral and Catharina Lavebratt and Giorgio Tettamanti and Joachim Sch{\"u}z and Martin R{\"o}{\"o}sli and Kristina Kjaerheim and Grotzer, {Michael A} and Christoffer Johansen and Kuehni, {Claudia E} and Birgitta Lannering and Schmidt, {Lisbeth S} and Hatef Darabi and Maria Feychting",
year = "2019",
month = "12",
day = "2",
doi = "10.1038/s41598-019-54701-1",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk

AU - Adel Fahmideh, Maral

AU - Lavebratt, Catharina

AU - Tettamanti, Giorgio

AU - Schüz, Joachim

AU - Röösli, Martin

AU - Kjaerheim, Kristina

AU - Grotzer, Michael A

AU - Johansen, Christoffer

AU - Kuehni, Claudia E

AU - Lannering, Birgitta

AU - Schmidt, Lisbeth S

AU - Darabi, Hatef

AU - Feychting, Maria

PY - 2019/12/2

Y1 - 2019/12/2

N2 - Genetic risk score (GRS) is used to demonstrate the genetic variants contributing to the polygenic architecture of complex diseases. By using a GRS, we have investigated the additive impact of the known adult glioma susceptibility loci on the pediatric brain tumor (PBT) risk and assessed the proportion of PBT heritability attributable to these susceptibility loci. A GRS was generated for PBTs based on the alleles and associated effect sizes derived from a previously published genome-wide association study on adult glioma. The GRS was calculated in CEFALO, a population-based case-control study of brain tumors in children and adolescents including saliva DNA of 245 cases and 489 controls. The unconditional logistic regression model was used to investigate the association between standardized GRS and risk of PBTs. To measure the variance explained by the effect of GRS, Nagelkerke pseudo-R2 was calculated. The GRS for adult brain tumors was associated with an increased risk of PBTs (OR 1.25 [95% CI 1.06-1.49], p = 0.009) and 0.3% of the variance in PBTs could be explained by the effect of GRS on the liability scale. This study provides evidence that heritable risks of PBTs are in-part attributable to some common genetic variants associated with adult glioma.

AB - Genetic risk score (GRS) is used to demonstrate the genetic variants contributing to the polygenic architecture of complex diseases. By using a GRS, we have investigated the additive impact of the known adult glioma susceptibility loci on the pediatric brain tumor (PBT) risk and assessed the proportion of PBT heritability attributable to these susceptibility loci. A GRS was generated for PBTs based on the alleles and associated effect sizes derived from a previously published genome-wide association study on adult glioma. The GRS was calculated in CEFALO, a population-based case-control study of brain tumors in children and adolescents including saliva DNA of 245 cases and 489 controls. The unconditional logistic regression model was used to investigate the association between standardized GRS and risk of PBTs. To measure the variance explained by the effect of GRS, Nagelkerke pseudo-R2 was calculated. The GRS for adult brain tumors was associated with an increased risk of PBTs (OR 1.25 [95% CI 1.06-1.49], p = 0.009) and 0.3% of the variance in PBTs could be explained by the effect of GRS on the liability scale. This study provides evidence that heritable risks of PBTs are in-part attributable to some common genetic variants associated with adult glioma.

U2 - 10.1038/s41598-019-54701-1

DO - 10.1038/s41598-019-54701-1

M3 - Journal article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 18142

ER -

ID: 59234725