Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Glycemic control and use of glucose-lowering medications in hospital-admitted type 2 diabetes patients over 80 years

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Describing the fecal metabolome in cryogenically collected samples from healthy participants

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Psychological stress in long-term testicular cancer survivors: a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Depressive symptoms and mental health-related quality of life in adolescence and young adulthood after early parental death

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  • Maral Adel Fahmideh
  • Catharina Lavebratt
  • Giorgio Tettamanti
  • Joachim Schüz
  • Martin Röösli
  • Kristina Kjaerheim
  • Michael A Grotzer
  • Christoffer Johansen
  • Claudia E Kuehni
  • Birgitta Lannering
  • Lisbeth S Schmidt
  • Hatef Darabi
  • Maria Feychting
View graph of relations

Genetic risk score (GRS) is used to demonstrate the genetic variants contributing to the polygenic architecture of complex diseases. By using a GRS, we have investigated the additive impact of the known adult glioma susceptibility loci on the pediatric brain tumor (PBT) risk and assessed the proportion of PBT heritability attributable to these susceptibility loci. A GRS was generated for PBTs based on the alleles and associated effect sizes derived from a previously published genome-wide association study on adult glioma. The GRS was calculated in CEFALO, a population-based case-control study of brain tumors in children and adolescents including saliva DNA of 245 cases and 489 controls. The unconditional logistic regression model was used to investigate the association between standardized GRS and risk of PBTs. To measure the variance explained by the effect of GRS, Nagelkerke pseudo-R2 was calculated. The GRS for adult brain tumors was associated with an increased risk of PBTs (OR 1.25 [95% CI 1.06-1.49], p = 0.009) and 0.3% of the variance in PBTs could be explained by the effect of GRS on the liability scale. This study provides evidence that heritable risks of PBTs are in-part attributable to some common genetic variants associated with adult glioma.

Original languageEnglish
Article number18142
JournalScientific Reports
Volume9
ISSN2045-2322
DOIs
Publication statusPublished - 2 Dec 2019

ID: 59234725