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A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice

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Thrane, Susan ; Aves, Kara-Lee ; Uddbäck, Ida E M ; Janitzek, Christoph M ; Han, Julianna ; Yang, Yuhe R ; Ward, Andrew B ; Theander, Thor G ; Nielsen, Morten A ; Salanti, Ali ; Thomsen, Allan R ; Christensen, Jan P ; Sander, Adam F. / A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice. In: Vaccines. 2020 ; Vol. 8, No. 3.

Bibtex

@article{4c31bcc736a8467891f516c255a5cdee,
title = "A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice",
abstract = "Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose.",
author = "Susan Thrane and Kara-Lee Aves and Uddb{\"a}ck, {Ida E M} and Janitzek, {Christoph M} and Julianna Han and Yang, {Yuhe R} and Ward, {Andrew B} and Theander, {Thor G} and Nielsen, {Morten A} and Ali Salanti and Thomsen, {Allan R} and Christensen, {Jan P} and Sander, {Adam F}",
year = "2020",
month = jul,
day = "15",
doi = "10.3390/vaccines8030389",
language = "English",
volume = "8",
journal = "Vaccines",
issn = "1554-8600",
publisher = "Landes Bioscience",
number = "3",

}

RIS

TY - JOUR

T1 - A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice

AU - Thrane, Susan

AU - Aves, Kara-Lee

AU - Uddbäck, Ida E M

AU - Janitzek, Christoph M

AU - Han, Julianna

AU - Yang, Yuhe R

AU - Ward, Andrew B

AU - Theander, Thor G

AU - Nielsen, Morten A

AU - Salanti, Ali

AU - Thomsen, Allan R

AU - Christensen, Jan P

AU - Sander, Adam F

PY - 2020/7/15

Y1 - 2020/7/15

N2 - Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose.

AB - Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose.

U2 - 10.3390/vaccines8030389

DO - 10.3390/vaccines8030389

M3 - Journal article

C2 - 32679905

VL - 8

JO - Vaccines

JF - Vaccines

SN - 1554-8600

IS - 3

ER -

ID: 62343880