Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Local complement activation is associated with primary graft dysfunction after lung transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Longitudinal analysis of naturally acquired PfEMP1 CIDR domain variant antibodies identifies associations with malaria protection

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Prehospital plasma is associated with distinct biomarker expression following injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long-term monitoring of intracranial pressure in freely-moving rats; impact of different physiological states

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Michael W O'Reilly
  • Connar Sj Westgate
  • Catherine Hornby
  • Hannah Botfield
  • Angela E Taylor
  • Keira Markey
  • James L Mitchell
  • William J Scotton
  • Susan P Mollan
  • Andreas Yiangou
  • Carl Jenkinson
  • Lorna C Gilligan
  • Mark Sherlock
  • James Gibney
  • Jeremy W Tomlinson
  • Gareth G Lavery
  • David J Hodson
  • Wiebke Arlt
  • Alexandra J Sinclair
View graph of relations

Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated intracranial pressure frequently manifesting with chronic headaches and visual loss. Similar to polycystic ovary syndrome (PCOS), IIH predominantly affects obese women of reproductive age. In this study, we comprehensively examined the systemic and cerebrospinal fluid (CSF) androgen metabolome in women with IIH in comparison with sex-, BMI-, and age-matched control groups with either simple obesity or PCOS (i.e., obesity and androgen excess). Women with IIH showed a pattern of androgen excess distinct to that observed in PCOS and simple obesity, with increased serum testosterone and increased CSF testosterone and androstenedione. Human choroid plexus expressed the androgen receptor, alongside the androgen-activating enzyme aldoketoreductase type 1C3. We show that in a rat choroid plexus cell line, testosterone significantly enhanced the activity of Na+/K+-ATPase, a surrogate of CSF secretion. We demonstrate that IIH patients have a unique signature of androgen excess and provide evidence that androgens can modulate CSF secretion via the choroid plexus. These findings implicate androgen excess as a potential causal driver and therapeutic target in IIH.

Original languageEnglish
JournalJCI Insight
Volume4
Issue number6
Pages (from-to)e125348
ISSN2379-3708
DOIs
Publication statusPublished - 2019
Externally publishedYes

ID: 58957867