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A systematic review of blood-based serotonergic biomarker in Bulimia Nervosa

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@article{f3d0beb5a9414ff3bbbde05a623e25dd,
title = "A systematic review of blood-based serotonergic biomarker in Bulimia Nervosa",
abstract = "Bulimia Nervosa (BN) is a serious eating disorder, which affects 0.8–2.9{\%} of the young population. The etiology is unknown and biomarkers would support in understanding the pathophysiology of BN, and in identifying BN patients that may benefit from medical treatment. This systematic review aims to answer whether (a) BN deviate from healthy controls in terms of serotonin (5-HT) biomarkers in blood, and whether (b) blood-based 5-HT biomarkers could be used to tailor psychopharmacological treatment in BN. A literature search using PubMed, PsycINFO and Embase was done using the following search terms: “Bulimia Nervosa” AND “serotonin” AND “blood” OR “plasma” OR “serum”. 32 studies were included in this systematic review. Several biomarkers and challenge tests were identified and all studies described an association with BN and dysregulation of the 5-HT system compared to healthy controls. Several studies pointed to an association also to borderline symptoms in BN. BN deviate from healthy controls in terms of 5-HT biomarkers in blood supporting an abnormal 5-HT system in BN. 5-HT biomarkers and associated methods could be used to tailor treatment in BN although as yet, most tests described are unpractical for bedside use.",
keywords = "Health Sciences, Eating Disorders, Anorexia Nervosa, Bulimia nervosa, Serotonin, biomarker",
author = "Sj{\"o}gren, {Jan Magnus} and Nielsen, {Anna Skovgaard M{\o}ller} and Hasselbalch, {Katharina Collin} and Maria W{\o}llo and Hansen, {Jitka Stilund}",
year = "2019",
month = "9",
doi = "10.1016/j.psychres.2018.12.167",
language = "English",
volume = "279",
pages = "155--171",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - A systematic review of blood-based serotonergic biomarker in Bulimia Nervosa

AU - Sjögren, Jan Magnus

AU - Nielsen , Anna Skovgaard Møller

AU - Hasselbalch , Katharina Collin

AU - Wøllo, Maria

AU - Hansen, Jitka Stilund

PY - 2019/9

Y1 - 2019/9

N2 - Bulimia Nervosa (BN) is a serious eating disorder, which affects 0.8–2.9% of the young population. The etiology is unknown and biomarkers would support in understanding the pathophysiology of BN, and in identifying BN patients that may benefit from medical treatment. This systematic review aims to answer whether (a) BN deviate from healthy controls in terms of serotonin (5-HT) biomarkers in blood, and whether (b) blood-based 5-HT biomarkers could be used to tailor psychopharmacological treatment in BN. A literature search using PubMed, PsycINFO and Embase was done using the following search terms: “Bulimia Nervosa” AND “serotonin” AND “blood” OR “plasma” OR “serum”. 32 studies were included in this systematic review. Several biomarkers and challenge tests were identified and all studies described an association with BN and dysregulation of the 5-HT system compared to healthy controls. Several studies pointed to an association also to borderline symptoms in BN. BN deviate from healthy controls in terms of 5-HT biomarkers in blood supporting an abnormal 5-HT system in BN. 5-HT biomarkers and associated methods could be used to tailor treatment in BN although as yet, most tests described are unpractical for bedside use.

AB - Bulimia Nervosa (BN) is a serious eating disorder, which affects 0.8–2.9% of the young population. The etiology is unknown and biomarkers would support in understanding the pathophysiology of BN, and in identifying BN patients that may benefit from medical treatment. This systematic review aims to answer whether (a) BN deviate from healthy controls in terms of serotonin (5-HT) biomarkers in blood, and whether (b) blood-based 5-HT biomarkers could be used to tailor psychopharmacological treatment in BN. A literature search using PubMed, PsycINFO and Embase was done using the following search terms: “Bulimia Nervosa” AND “serotonin” AND “blood” OR “plasma” OR “serum”. 32 studies were included in this systematic review. Several biomarkers and challenge tests were identified and all studies described an association with BN and dysregulation of the 5-HT system compared to healthy controls. Several studies pointed to an association also to borderline symptoms in BN. BN deviate from healthy controls in terms of 5-HT biomarkers in blood supporting an abnormal 5-HT system in BN. 5-HT biomarkers and associated methods could be used to tailor treatment in BN although as yet, most tests described are unpractical for bedside use.

KW - Health Sciences

KW - Eating Disorders

KW - Anorexia Nervosa

KW - Bulimia nervosa

KW - Serotonin

KW - biomarker

U2 - 10.1016/j.psychres.2018.12.167

DO - 10.1016/j.psychres.2018.12.167

M3 - Journal article

VL - 279

SP - 155

EP - 171

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

ER -

ID: 56527186