Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A systematic review of blood-based serotonergic biomarker in Bulimia Nervosa

Research output: Contribution to journalJournal articleResearchpeer-review

  1. PTSD with secondary psychotic features among trauma-affected refugees: The role of torture and depression

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Does childhood trauma predict poorer metacognitive abilities in people with first-episode psychosis?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sensory processing sensitivity and its association with seasonal affective disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Case report: cognitive performance in an extreme case of anorexia nervosa with a body mass index of 7.7

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Slime-loving bacteria from fresh faeces may be able to help anorexia patients

    Research output: Contribution to journalJournal articleCommunication

  3. Hvorfor fravælger halvdelen behandling for en spiseforstyrrelse?

    Research output: Contribution to journalContribution to newspaper - Newspaper articleCommunication

  4. On motivation as a Target for Intervention in Anorexia Nervosa

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. An update on psychopharmacological treatment of Body Dysmorphic Disorder (BDD)

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Bulimia Nervosa (BN) is a serious eating disorder, which affects 0.8–2.9% of the young population. The etiology is unknown and biomarkers would support in understanding the pathophysiology of BN, and in identifying BN patients that may benefit from medical treatment. This systematic review aims to answer whether (a) BN deviate from healthy controls in terms of serotonin (5-HT) biomarkers in blood, and whether (b) blood-based 5-HT biomarkers could be used to tailor psychopharmacological treatment in BN. A literature search using PubMed, PsycINFO and Embase was done using the following search terms: “Bulimia Nervosa” AND “serotonin” AND “blood” OR “plasma” OR “serum”. 32 studies were included in this systematic review. Several biomarkers and challenge tests were identified and all studies described an association with BN and dysregulation of the 5-HT system compared to healthy controls. Several studies pointed to an association also to borderline symptoms in BN. BN deviate from healthy controls in terms of 5-HT biomarkers in blood supporting an abnormal 5-HT system in BN. 5-HT biomarkers and associated methods could be used to tailor treatment in BN although as yet, most tests described are unpractical for bedside use.
Original languageEnglish
JournalPsychiatry Research
Volume279
Pages (from-to)155-171
Number of pages17
ISSN0165-1781
DOIs
Publication statusPublished - Sep 2019

    Research areas

  • Health Sciences - Eating Disorders, Anorexia Nervosa, Bulimia nervosa, Serotonin, biomarker

ID: 56527186