Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A Systematic Review and Meta-Analysis Finds Increased Blood Levels of All Forms of Ghrelin in Both Restricting and Binge-Eating/Purging Subtypes of Anorexia Nervosa

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Explanatory Factors for Disease-Specific Health-Related Quality of Life in Women with Anorexia Nervosa

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cognitive function in adults with enduring anorexia nervosa

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Maria Seidel
  • Signe Markmann Jensen
  • Darren Healy
  • Aakriti Dureja
  • Hunna J Watson
  • Birgitte Holst
  • Cynthia M Bulik
  • Jan Magnus Sjögren
View graph of relations

Anorexia nervosa (AN) is a severe psychiatric condition associated with high mortality and chronicity. The hunt for state, trait, subtyping, and prognostic biomarkers is ongoing and the orexigenic hormone ghrelin and its different forms, acyl ghrelin and desacyl ghrelin, have been proposed to be increased in AN, especially in the restrictive subtype. A systematic literature search was performed using established databases up to 30 November 2020. Forty-nine studies met inclusion criteria for cross-sectional and longitudinal meta-analyses on total ghrelin, acyl ghrelin, and desacyl ghrelin. All forms of ghrelin were increased in the acute stage of anorexia nervosa during fasting compared to healthy controls. Previous notions on differences in ghrelin levels between AN subtypes were not supported by current data. In addition, a significant decrease in total ghrelin was observed pre-treatment to follow-up. However, total ghrelin levels at follow-up were still marginally elevated compared to healthy controls, whereas for acyl ghrelin, no overall effect of treatment was observed. Due to heterogeneity in follow-up designs and only few data on long-term recovered patients, longitudinal results should be interpreted with caution. While the first steps towards a biomarker in acute AN have been completed, the value of ghrelin as a potential indicator of treatment success or recovery status or its use in subtype differentiation are yet to be established.

Original languageEnglish
Article number709
JournalNutrients
Volume13
Issue number2
Pages (from-to)1-19
Number of pages19
ISSN2072-6643
DOIs
Publication statusPublished - 23 Feb 2021

    Research areas

  • Acyl ghrelin, Anorexia nervosa, Desacyl ghrelin, Eating disorders, Ghrelin, Meta-analysis, Systematic re-view

ID: 64182286