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A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22

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The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.

Original languageEnglish
JournalCellular Signalling
Volume11
Issue number526
ISSN0898-6568
DOIs
Publication statusPublished - 17 Apr 2018

ID: 54977790