A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22

Torkel Vang; Jimmi Nielsen; Garth L Burn

doi:10.1126/scisignal.aat0936

A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22

Torkel Vang
, Jimmi Nielsen
, Garth L Burn

Psykiatrisk Center Glostrup

12 Citations (Scopus)

Abstract

The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.

Original language	English
Journal	Cellular Signalling
Volume	11
Issue number	526
ISSN	0898-6568
DOIs	https://doi.org/10.1126/scisignal.aat0936
Publication status	Published - 17 Apr 2018

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title = "A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22",

abstract = "The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new {"}switch-of-function{"} model.",

author = "Torkel Vang and Jimmi Nielsen and Burn, \{Garth L\}",

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AU - Nielsen, Jimmi

AU - Burn, Garth L

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N2 - The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.

AB - The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.

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M3 - Review

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SN - 0898-6568

VL - 11

JO - Cellular Signalling

JF - Cellular Signalling

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A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22

Abstract

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