Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A single administration of glucocorticoid increases exercise capacity in men with stable chronic obstructive pulmonary disease

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Improving colonoscopy quality through individualised training programmes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Characteristics of patients with COVID-19 pneumonia at Hvidovre Hospital, March-April 2020

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Trends of ankyloglossia and lingual frenotomy in hospital settings among children in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Distribution of risk alleles in patients with age-related macular degeneration

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Outcomes and follow-up programmes in extreme preterm children in Denmark in the EPICE/SHIPS cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Airway hyperresponsiveness to mannitol improves in both type 2 high and type 2 low asthma after specialist management

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The six-gene expression signature in whole sampled sputum provides clinically feasible inflammatory phenotyping of asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Fertility Treatment Resulting in Live Births in Women with Asthma - Associated with Perennial Allergy?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. High suPAR and Low Blood Eosinophil Count are Risk Factors for Hospital Readmission and Mortality in Patients with COPD

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Oral use of glucocorticoids is a well-described therapy in the treatment of acute exacerbations of chronic obstructive pulmonary disease (COPD). Patients with COPD occasionally report subjective benefits of glucocorticoids in terms of fewer symptoms and better exercise performance, even when they do not experience exacerbation. This study investigated whether a single high therapeutic dose of oral glucocorticoid improves short-term exercise tolerance in patients with moderate-to-very severe COPD.

METHODS: In a double-blinded crossover design, patients were randomised to either 100 mg of prednisolone or placebo. The study consisted of a baseline visit and two study visits, each seven days apart. The primary endpoint was time to exhaustion (TTE) on an ergometer bike using a submaximal exercise test on 70% of the maximal workload. On every study visit, spirometry, the COPD Assessment Test, maximal inspiratory/expiratory pressure and maximal voluntary contraction of the quadriceps muscle were measured. A total of 14 male patients with grade C/D COPD were randomised.

RESULTS: The mean TTE was significantly longer at the prednisolone visit (p = 0.019), whereas no differences were seen on other parameters such as lung function, respiratory symptoms or muscle strength.

CONCLUSION: Our finding suggests that COPD patients experience improvements in exercise tolerance from a single high dose of glucocorticoid even in the stable phase of their disease.

FUNDING: none.

TRIAL REGISTRATION: EudraCT 2012-004503-13.

Original languageEnglish
JournalDanish Medical Journal
Volume66
Issue number1
ISSN1603-9629
Publication statusPublished - Jan 2019

ID: 56147724