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A short history of neuroendocrine tumours and their peptide hormones

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  1. Genetic and non-iodine-related factors in the aetiology of nodular goitre

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  2. The metabolic syndrome in HIV

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  3. Endocrine disorders in pregnancy: physiological and hormonal aspects of pregnancy

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  4. Genital anomalies in boys and the environment

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  5. Iodine intake as a determinant of thyroid disorders in populations

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  1. Dairy products influence gut hormone secretion and appetite differently: A randomized controlled crossover trial

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  2. Intestinal sensing and handling of dietary lipids in gastric bypass-operated patients and matched controls

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  3. Gastric peptides - gastrin and somatostatin

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  4. Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia

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The discovery of neuroendocrine tumours of the gastrointestinal tract and pancreas started in 1870, when Rudolf Heidenhain discovered the neuroendocrine cells, which can lead to the development of these tumours. Siegfried Oberndorfer was the first to introduce the term carcinoid in 1907. The pancreatic islet cells were first described in 1869 by Paul Langerhans. In 1924, Seale Harris was the first to describe endogenous hyperinsulinism/insulinoma. In 1942 William Becker and colleagues were the first to describe the glucagonoma syndrome. The first description of gastrinoma by Robert Zollinger and Edwin Ellison dates from 1955. The first description of the VIPoma syndrome by John Verner and Ashton Morrison dates from 1958. In 1977, the groups of Lars-Inge Larsson and Jens Rehfeld, and of Om Ganda reported the first cases of somatostatinoma. But only in 2013, Jens Rehfeld and colleagues described the CCK-oma syndrome. The most recently updated WHO classification for gastrointestinal neuroendocrine tumours dates from 2010.

Original languageEnglish
JournalBest Practice and Research in Clinical Endocrinology and Metabolism
Volume30
Issue number1
Pages (from-to)3-17
Number of pages15
ISSN1521-690X
DOIs
Publication statusPublished - Jan 2016

    Research areas

  • Journal Article, Review

ID: 49296706