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The Capital Region of Denmark - a part of Copenhagen University Hospital
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A short history of microbial biofilms and biofilm infections

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  1. Primary antibiotic resistance of Helicobacter pylori strains among adults and children in a tertiary referral centre in Lithuania

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  2. Biofilms and host response - helpful or harmful

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  3. Diagnosis of biofilm infections in cystic fibrosis patients

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  1. Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis

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  2. Antibody response against Mycobacterium avium complex in cystic fibrosis patients measured by a novel IgG ELISA test

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  3. The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis

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  4. Next generation microbiology and cystic fibrosis diagnostics: are we there yet?

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  5. The accessibility of topical treatment in the paranasal sinuses on operated cystic fibrosis patients assessed by scintigraphy

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The observation of aggregated microbes surrounded by a self-produced matrix adhering to surfaces or located in tissues or secretions is old since both Leeuwenhoek and Pasteur have described the phenomenon. In environmental and technical microbiology, biofilms, 80-90 years ago, were already shown to be important for biofouling on submerged surfaces, for example, ships. The concept of biofilm infections and their importance in medicine was, however, initiated in the early 1970s by the observation of heaps of Pseudomonas aeruginosa cells in sputum and lung tissue from chronically infected cystic fibrosis patients. The term biofilm was introduced into medicine in 1985 by J. W. Costerton. During the following decades, the number of published biofilm articles and methods for studying biofilms increased rapidly and it was shown that adhering and nonadhering biofilm infections are widespread in medicine. The medical importance of biofilm infections is now generally accepted and guidelines for prophylaxis, diagnosis, and treatment have been published.

Original languageEnglish
JournalAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Volume125
Issue number4
Pages (from-to)272-275
Number of pages4
ISSN0365-5555
DOIs
Publication statusPublished - Apr 2017

    Research areas

  • Animals, Biofilms, Cystic Fibrosis, History, 17th Century, History, 18th Century, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Microbiology, Pseudomonas Infections, Pseudomonas aeruginosa, Historical Article, Journal Article, Review

ID: 52096931