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A review of bone metabolism and developments in medical treatment of the diabetic Charcot foot

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  1. Healing of Diabetic Foot Ulcers in Patients Treated at the Copenhagen Wound Healing Center in 1999/2000 and in 2011/2012

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  2. Mortality and complications after treatment of acute diabetic Charcot foot

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  3. Long-term effects on the progress of neuropathy after diabetic Charcot foot: an 8.5-year prospective case-control study

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  4. Risk Factors for Premature Death in Diabetes Patients who Undergo Amputations below Ankle Level

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Charcot foot is a rare but severe, and possibly limb-threatening, complication to neuropathy and diabetes mellitus. The current treatment consists of long-term off-loading, and has a large negative impact on the patient's life. Much research has gone into understanding the condition and its biochemical mechanisms, however, the underlying pathogenesis of a Charcot foot is not yet fully understood. In the recent decades several key advances in our understanding of the Charcot foot have been made, both in regards to the changes in bone metabolism and structure an acute Charcot foot can cause, and to the molecular pathways involved in this. This review summerizes the available research into the bone metabolism around a Charcot foot, with an emphasis on the biochemical profile. The existing data regarding attempts at medical treatment is also reviewed, including novel trials targetting specific inflammatory pathways upregulated in the acute diabetic Charcot foot.

Original languageEnglish
JournalJournal of Diabetes and its Complications
Volume32
Issue number7
Pages (from-to)708-712
Number of pages5
ISSN1056-8727
DOIs
Publication statusPublished - Jul 2018

ID: 56256279