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A randomized double-blind crossover trial comparing subthalamic and pallidal deep brain stimulation for dystonia

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@article{e4c58a600a2e4b45b2d01f36c3d8b201,
title = "A randomized double-blind crossover trial comparing subthalamic and pallidal deep brain stimulation for dystonia",
abstract = "Object The authors' aim was to compare the subthalamic nucleus (STN) with the globus pallidus internus (GPi) as a stimulation target for deep brain stimulation (DBS) for medically refractory dystonia. Methods In a prospective double-blind crossover study, electrodes were bilaterally implanted in the STN and GPi of 12 patients with focal, multifocal, or generalized dystonia. Each patient was randomly selected to undergo initial bilateral stimulation of either the STN or the GPi for 6 months, followed by bilateral stimulation of the other nucleus for another 6 months. Preoperative and postoperative ratings were assessed by using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and video recordings. Quality of life was evaluated by using questionnaires (36-item Short Form Health Survey). Supplemental Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scores were assessed for patients with focal dystonia (torticollis) by examining the video recordings. Results On average for all patients, DBS improved the BFMDRS movement scores (p ",
author = "Lisbeth Schjerling and Hjermind, {Lena E} and Bo Jespersen and Madsen, {Flemming F} and Jannick Brennum and Jensen, {Steen R} and Annemette L{\o}kkegaard and Merete Karlsborg",
year = "2013",
month = dec,
doi = "10.3171/2013.8.JNS13844",
language = "English",
volume = "119",
pages = "1537--45",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "6",

}

RIS

TY - JOUR

T1 - A randomized double-blind crossover trial comparing subthalamic and pallidal deep brain stimulation for dystonia

AU - Schjerling, Lisbeth

AU - Hjermind, Lena E

AU - Jespersen, Bo

AU - Madsen, Flemming F

AU - Brennum, Jannick

AU - Jensen, Steen R

AU - Løkkegaard, Annemette

AU - Karlsborg, Merete

PY - 2013/12

Y1 - 2013/12

N2 - Object The authors' aim was to compare the subthalamic nucleus (STN) with the globus pallidus internus (GPi) as a stimulation target for deep brain stimulation (DBS) for medically refractory dystonia. Methods In a prospective double-blind crossover study, electrodes were bilaterally implanted in the STN and GPi of 12 patients with focal, multifocal, or generalized dystonia. Each patient was randomly selected to undergo initial bilateral stimulation of either the STN or the GPi for 6 months, followed by bilateral stimulation of the other nucleus for another 6 months. Preoperative and postoperative ratings were assessed by using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and video recordings. Quality of life was evaluated by using questionnaires (36-item Short Form Health Survey). Supplemental Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scores were assessed for patients with focal dystonia (torticollis) by examining the video recordings. Results On average for all patients, DBS improved the BFMDRS movement scores (p

AB - Object The authors' aim was to compare the subthalamic nucleus (STN) with the globus pallidus internus (GPi) as a stimulation target for deep brain stimulation (DBS) for medically refractory dystonia. Methods In a prospective double-blind crossover study, electrodes were bilaterally implanted in the STN and GPi of 12 patients with focal, multifocal, or generalized dystonia. Each patient was randomly selected to undergo initial bilateral stimulation of either the STN or the GPi for 6 months, followed by bilateral stimulation of the other nucleus for another 6 months. Preoperative and postoperative ratings were assessed by using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and video recordings. Quality of life was evaluated by using questionnaires (36-item Short Form Health Survey). Supplemental Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scores were assessed for patients with focal dystonia (torticollis) by examining the video recordings. Results On average for all patients, DBS improved the BFMDRS movement scores (p

U2 - 10.3171/2013.8.JNS13844

DO - 10.3171/2013.8.JNS13844

M3 - Journal article

C2 - 24116723

VL - 119

SP - 1537

EP - 1545

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - 6

ER -

ID: 42329578