A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia

Philippe Duvaldestin; Karel Kuizenga; Vera Saldien; Casper Claudius; Frédérique Servin; Jan Klein; Bertrand Debaene; Marten Heeringa

doi:10.1213/ANE.0b013e3181c3be3c

A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia

Philippe Duvaldestin
, Karel Kuizenga
, Vera Saldien
, Casper Claudius
, Frédérique Servin
, Jan Klein
, Bertrand Debaene
, Marten Heeringa

Department of Anaesthesiology, Center of Head and Orthopaedic Surgery

145 Citations (Scopus)

Abstract

Sugammadex is the first of a new class of selective muscle relaxant binding drugs developed for the rapid and complete reversal of neuromuscular blockade induced by rocuronium and vecuronium. Many studies have demonstrated a dose-response relationship with sugammadex for reversal of neuromuscular blockade in patients induced and maintained under propofol anesthesia. However, sevoflurane anesthesia, unlike propofol, can prolong the effect of neuromuscular blocking drugs (NMBDs) such as rocuronium and vecuronium.

Original language	English
Journal	Anesthesia and Analgesia
Volume	110
Issue number	1
Pages (from-to)	74-82
Number of pages	9
ISSN	0003-2999
DOIs	https://doi.org/10.1213/ANE.0b013e3181c3be3c
Publication status	Published - 1 Jan 2010

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A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia. / Duvaldestin, Philippe; Kuizenga, Karel; Saldien, Vera et al.
In: Anesthesia and Analgesia, Vol. 110, No. 1, 01.01.2010, p. 74-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Duvaldestin, P, Kuizenga, K, Saldien, V, Claudius, C, Servin, F, Klein, J, Debaene, B & Heeringa, M 2010, 'A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia', Anesthesia and Analgesia, vol. 110, no. 1, pp. 74-82. https://doi.org/10.1213/ANE.0b013e3181c3be3c

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A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia

Abstract

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