A prospective study of nutritional status in immunoglobulin light chain amyloidosis

Prayman T Sattianayagam; Thirusha Lane; Zoe Fox; Aviva Petrie; Simon D J Gibbs; Jennifer H Pinney; Signe S Risom; Dorota M Rowczenio; Ashutosh D Wechalekar; Helen J Lachmann; Janet A Gilbertson; Philip N Hawkins; Julian D Gillmore

doi:10.3324/haematol.2012.070359

A prospective study of nutritional status in immunoglobulin light chain amyloidosis

Prayman T Sattianayagam, Thirusha Lane, Zoe Fox, Aviva Petrie, Simon D J Gibbs, Jennifer H Pinney, Signe S Risom, Dorota M Rowczenio, Ashutosh D Wechalekar, Helen J Lachmann, Janet A Gilbertson, Philip N Hawkins, Julian D Gillmore

30 Citations (Scopus)

Abstract

Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-naïve patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P

Original language	English
Journal	Haematologica
Volume	98
Issue number	1
Pages (from-to)	136-40
Number of pages	5
ISSN	0390-6078
DOIs	https://doi.org/10.3324/haematol.2012.070359
Publication status	Published - Jan 2013

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Sattianayagam, P. T., Lane, T., Fox, Z., Petrie, A., Gibbs, S. D. J., Pinney, J. H., Risom, S. S., Rowczenio, D. M., Wechalekar, A. D., Lachmann, H. J., Gilbertson, J. A., Hawkins, P. N., & Gillmore, J. D. (2013). A prospective study of nutritional status in immunoglobulin light chain amyloidosis. Haematologica, 98(1), 136-40. https://doi.org/10.3324/haematol.2012.070359

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abstract = "Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-na{\"i}ve patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66\%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P",

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AU - Sattianayagam, Prayman T

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AU - Gibbs, Simon D J

AU - Pinney, Jennifer H

AU - Risom, Signe S

AU - Rowczenio, Dorota M

AU - Wechalekar, Ashutosh D

AU - Lachmann, Helen J

AU - Gilbertson, Janet A

AU - Hawkins, Philip N

AU - Gillmore, Julian D

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AB - Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-naïve patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P

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A prospective study of nutritional status in immunoglobulin light chain amyloidosis

Abstract

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