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A portfolio of biologic self-injection devices in rheumatology: how patient involvement in device design can improve treatment experience

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  • Bart J F van den Bemt
  • Lynda Gettings
  • Barbara Domańska
  • Richard Bruggraber
  • Irina Mountian
  • Lars E Kristensen
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Biologic drugs (e.g. anti-tumor necrosis factors) are effective treatments for multiple chronic inflammatory diseases including rheumatoid arthritis, axial spondyloarthritis, and psoriatic arthritis. Administration of biologic drugs is usually via subcutaneous self-injection, which provides many patient benefits compared to infusions including increased flexibility, reduced costs, and reduced caregiver burden. However, it is also associated with challenges such as needle phobia, patient treatment misconceptions and incorrect drug administration, and can be impacted by dexterity problems. Evidence suggests these problems, along with other drug administration challenges (e.g. patient forgetfulness, busy lifestyles, and polypharmacy), can reduce patient adherence to treatment. To combat these challenges, patient feedback has been used to develop a range of self-injection devices, including pre-filled syringes, pre-filled pens, and electronic injection devices. Providing different devices for drug administration gives patients the opportunity to choose a device that addresses the challenges they face as an individual. Research suggests involving patients in medical device development, providing patients with a choice of devices and enrolling individuals in patient support programs can empower patients to take control of their treatment journey. By providing a portfolio of self-injection devices, designed based on patient needs, patient experience will improve, potentially improving adherence and hence, long-term treatment outcomes.

Original languageEnglish
JournalDrug Delivery
Issue number1
Pages (from-to)384-392
Number of pages9
Publication statusPublished - Dec 2019

    Research areas

  • Anti-TNF, electronic injection device, pre-filled pen, pre-filled syringe, self-injection, Rheumatic Diseases/drug therapy, Humans, Antirheumatic Agents/administration & dosage, Equipment Design, Medication Adherence, Self Administration, Animals, Biological Products/administration & dosage, Syringes, Injections, Subcutaneous

ID: 57027414