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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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  • Xueyi Shen
  • David M. Howard
  • Mark J. Adams
  • W. David Hill
  • Toni Kim Clarke
  • Mark J. Adams
  • Toni Kim Clarke
  • Andrew M. McIntosh
  • Ian J. Deary
  • Naomi R. Wray
  • Stephan Ripke
  • Manuel Mattheisen
  • Maciej Trzaskowski
  • Enda M. Byrne
  • Abdel Abdellaoui
  • Esben Agerbo
  • Tracy M. Air
  • Till F.M. Andlauer
  • Silviu Alin Bacanu
  • Marie Bækvad-Hansen
  • Aartjan T.F. Beekman
  • Tim B. Bigdeli
  • Elisabeth B. Binder
  • Julien Bryois
  • Henriette N. Buttenschøn
  • Jonas Bybjerg-Grauholm
  • Na Cai
  • Enrique Castelao
  • Jane Hvarregaard Christensen
  • Jonathan R.I. Coleman
  • Lucía Colodro-Conde
  • Baptiste Couvy-Duchesne
  • Nick Craddock
  • Gregory E. Crawford
  • Gail Davies
  • Franziska Degenhardt
  • Eske M. Derks
  • Nese Direk
  • Conor V. Dolan
  • Erin C. Dunn
  • Thalia C. Eley
  • Valentina Escott-Price
  • Farnush Farhadi Hassan Kiadeh
  • Hilary K. Finucane
  • Jerome C. Foo
  • Thomas F. Hansen
  • Wesley Thompson
  • Shantel Marie Weinsheimer
  • Merete Nordentoft
  • Thomas Werge
  • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
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Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, p FDR  < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, p FDR: 0.049 to 1.28 × 10 -14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.

Original languageEnglish
JournalNature Communications
Volume11
Issue number1
Pages (from-to)2301
ISSN2041-1723
DOIs
Publication statusPublished - 8 May 2020

    Research areas

  • Aged, Biological Specimen Banks, Depression/genetics, Female, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Neuroimaging/methods, Polymorphism, Single Nucleotide/genetics, Prefrontal Cortex/metabolism, Risk Factors

ID: 60936025