A phase 2/3, multicenter, randomized, double-masked, 2-year trial of pegaptanib sodium for the treatment of diabetic macular edema

Marla B Sultan; Duo Zhou; Jane Loftus; Theresa Dombi; Kathleen S Ice; Macugen 1013 Study Group; Michael Larsen

doi:10.1016/j.ophtha.2011.02.045

A phase 2/3, multicenter, randomized, double-masked, 2-year trial of pegaptanib sodium for the treatment of diabetic macular edema

Marla B Sultan
, Duo Zhou
, Jane Loftus
, Theresa Dombi
, Kathleen S Ice
, Macugen 1013 Study Group
, Michael Larsen

Department of Ophthalmology

156 Citations (Scopus)

Abstract

To confirm the safety and compare the efficacy of intravitreal pegaptanib sodium 0.3 mg versus sham injections in subjects with diabetic macular edema (DME) involving the center of the macula associated with vision loss not due to ischemia.

Original language	English
Journal	Ophthalmology
Volume	118
Issue number	6
Pages (from-to)	1107-18
Number of pages	12
ISSN	0161-6420
DOIs	https://doi.org/10.1016/j.ophtha.2011.02.045
Publication status	Published - 2011

Keywords

Adult
Aged
Aged, 80 and over
Aptamers, Nucleotide
Diabetic Retinopathy
Dose-Response Relationship, Drug
Female
Fluorescein Angiography
Fundus Oculi
Humans
Intravitreal Injections
Macula Lutea
Macular Edema
Male
Middle Aged
Treatment Outcome
Vascular Endothelial Growth Factor A
Visual Acuity
Young Adult

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10.1016/j.ophtha.2011.02.045

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title = "A phase 2/3, multicenter, randomized, double-masked, 2-year trial of pegaptanib sodium for the treatment of diabetic macular edema",

abstract = "To confirm the safety and compare the efficacy of intravitreal pegaptanib sodium 0.3 mg versus sham injections in subjects with diabetic macular edema (DME) involving the center of the macula associated with vision loss not due to ischemia.",

keywords = "Adult, Aged, Aged, 80 and over, Aptamers, Nucleotide, Diabetic Retinopathy, Dose-Response Relationship, Drug, Female, Fluorescein Angiography, Fundus Oculi, Humans, Intravitreal Injections, Macula Lutea, Macular Edema, Male, Middle Aged, Treatment Outcome, Vascular Endothelial Growth Factor A, Visual Acuity, Young Adult",

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doi = "10.1016/j.ophtha.2011.02.045",

language = "English",

volume = "118",

pages = "1107--18",

journal = "Ophthalmology",

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T1 - A phase 2/3, multicenter, randomized, double-masked, 2-year trial of pegaptanib sodium for the treatment of diabetic macular edema

AU - Sultan, Marla B

AU - Zhou, Duo

AU - Loftus, Jane

AU - Dombi, Theresa

AU - Ice, Kathleen S

AU - Macugen 1013 Study Group

AU - Larsen, Michael

PY - 2011

Y1 - 2011

N2 - To confirm the safety and compare the efficacy of intravitreal pegaptanib sodium 0.3 mg versus sham injections in subjects with diabetic macular edema (DME) involving the center of the macula associated with vision loss not due to ischemia.

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KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aptamers, Nucleotide

KW - Diabetic Retinopathy

KW - Dose-Response Relationship, Drug

KW - Female

KW - Fluorescein Angiography

KW - Fundus Oculi

KW - Humans

KW - Intravitreal Injections

KW - Macula Lutea

KW - Macular Edema

KW - Male

KW - Middle Aged

KW - Treatment Outcome

KW - Vascular Endothelial Growth Factor A

KW - Visual Acuity

KW - Young Adult

U2 - 10.1016/j.ophtha.2011.02.045

DO - 10.1016/j.ophtha.2011.02.045

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SN - 0161-6420

VL - 118

SP - 1107

EP - 1118

JO - Ophthalmology

JF - Ophthalmology

IS - 6

ER -

A phase 2/3, multicenter, randomized, double-masked, 2-year trial of pegaptanib sodium for the treatment of diabetic macular edema

Abstract

Keywords

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