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The Capital Region of Denmark - a part of Copenhagen University Hospital
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A novel endoscopic ultrasound-guided through-the-needle microbiopsy procedure improves diagnosis of pancreatic cystic lesions

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  1. Endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic lesions: striving for perfection

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  2. Intraductal tubulopapillary neoplasm of the pancreas diagnosed by endoscopic ultrasonography-guided fine needle aspiration

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  3. All-cause mortality after ERCP

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  1. Esophageal stenting for benign and malignant disease: European Society of Gastrointestinal Endoscopy (ESGE) Cascade Guideline

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  2. Chronic Pancreatitis Is Characterized by Distinct Complication Clusters That Associate With Etiological Risk Factors

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  3. Subtyping of intraductal papillary mucinous neoplasms - pitfalls of MUC1 immunohistochemistry

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BACKGROUND:  Pancreatic cystic lesions represent a diagnostic dilemma as some may harbor malignancy or have potential for malignant transformation. The aim of this study was to present our experience with a novel endoscopic ultrasound (EUS)-guided microbiopsy procedure enabling procurement of tissue from the wall of the cystic lesion.

METHODS:  We collected data from 31 consecutive patients with pancreatic cystic lesions who underwent an EUS-guided microbiopsy procedure at our institution. Records were retrospectively reviewed from a prospectively maintained database.

RESULTS:  The technical success was 87.1 %. Diagnostic yield of microbiopsies was 71.0 %. Microbiopsies offered sufficient tissue for morphological and immunohistochemical characterization of the lesions, as well as determination of grade of dysplasia. Furthermore, evaluation of microbiopsies changed the clinical management in six patients (19.4 %). Three nonsevere adverse events were observed (9.7 %): two cases of mild infection and one case of mild pancreatitis. All three patients recovered completely.

CONCLUSIONS:  EUS-guided microbiopsy procedure was technically feasible, with a high diagnostic yield. Further prospective studies are needed to confirm these promising results.

Original languageEnglish
JournalEndoscopy
Volume50
Issue number11
Pages (from-to)1105-1111
ISSN0013-726X
DOIs
Publication statusPublished - 1 Dec 2018

ID: 54889135