A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers

Yuan C Ding; Lesley McGuffog; Sue Healey; Eitan Friedman; Yael Laitman; Shani- Paluch-Shimon; Bella Kaufman; Annelie Liljegren; Annika Lindblom; Håkan Olsson; Ulf Kristoffersson; Marie Stenmark-Askmalm; Beatrice Melin; Susan M Domchek; Katherine L Nathanson; Timothy R Rebbeck; Anna Jakubowska; Jan Lubinski; Katarzyna Jaworska; Katarzyna Durda; Jacek Gronwald; Tomasz Huzarski; Cezary Cybulski; Tomasz Byrski; Ana Osorio; Teresa Ramóny Cajal; Alexandra V Stavropoulou; Javier Benítez; Ute Hamann; Matti Rookus; Cora M Aalfs; Judith L de Lange; Hanne E J Meijers-Heijboer; Jan C Oosterwijk; Christi J van Asperen; Encarna B Gómez García; Nicoline Hoogerbrugge; Agnes Jager; Rob B van der Luijt; Douglas F Easton; Susan Peock; Debra Frost; Steve D Ellis; Radka Platte; Elena Fineberg; D Gareth Evans; Fiona Lalloo; Thomas V O Hansen; Bent Ejlertsen; Anne-Marie Gerdes; SWE-BRCA

doi:10.1158/1055-9965.EPI-12-0229

A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers

Yuan C Ding, Lesley McGuffog, Sue Healey, Eitan Friedman, Yael Laitman, Shani- Paluch-Shimon, Bella Kaufman, Annelie Liljegren, Annika Lindblom, Håkan Olsson, Ulf Kristoffersson, Marie Stenmark-Askmalm, Beatrice Melin, Susan M Domchek, Katherine L Nathanson, Timothy R Rebbeck, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna DurdaJacek Gronwald, Tomasz Huzarski, Cezary Cybulski, Tomasz Byrski, Ana Osorio, Teresa Ramóny Cajal, Alexandra V Stavropoulou, Javier Benítez, Ute Hamann, Matti Rookus, Cora M Aalfs, Judith L de Lange, Hanne E J Meijers-Heijboer, Jan C Oosterwijk, Christi J van Asperen, Encarna B Gómez García, Nicoline Hoogerbrugge, Agnes Jager, Rob B van der Luijt, Douglas F Easton, Susan Peock, Debra Frost, Steve D Ellis, Radka Platte, Elena Fineberg, D Gareth Evans, Fiona Lalloo, Thomas V O Hansen, Bent Ejlertsen, Anne-Marie Gerdes, SWE-BRCA

19 Citations (Scopus)

Abstract

We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.

Original language	English
Journal	Cancer Epidemiology, Biomarkers & Prevention
Volume	21
Issue number	8
Pages (from-to)	1362-70
Number of pages	9
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-12-0229
Publication status	Published - 2012

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Ding, Y. C., McGuffog, L., Healey, S., Friedman, E., Laitman, Y., Paluch-Shimon, S., Kaufman, B., Liljegren, A., Lindblom, A., Olsson, H., Kristoffersson, U., Stenmark-Askmalm, M., Melin, B., Domchek, S. M., Nathanson, K. L., Rebbeck, T. R., Jakubowska, A., Lubinski, J., Jaworska, K., ... SWE-BRCA (2012). A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention, 21(8), 1362-70. https://doi.org/10.1158/1055-9965.EPI-12-0229

A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. / Ding, Yuan C; McGuffog, Lesley; Healey, Sue et al.
In: Cancer Epidemiology, Biomarkers & Prevention, Vol. 21, No. 8, 2012, p. 1362-70.

Research output: Contribution to journal › Journal article › Research › peer-review

Ding, YC, McGuffog, L, Healey, S, Friedman, E, Laitman, Y, Paluch-Shimon, S, Kaufman, B, Liljegren, A, Lindblom, A, Olsson, H, Kristoffersson, U, Stenmark-Askmalm, M, Melin, B, Domchek, SM, Nathanson, KL, Rebbeck, TR, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Gronwald, J, Huzarski, T, Cybulski, C, Byrski, T, Osorio, A, Cajal, TR, Stavropoulou, AV, Benítez, J, Hamann, U, Rookus, M, Aalfs, CM, de Lange, JL, Meijers-Heijboer, HEJ, Oosterwijk, JC, van Asperen, CJ, Gómez García, EB, Hoogerbrugge, N, Jager, A, van der Luijt, RB, Easton, DF, Peock, S, Frost, D, Ellis, SD, Platte, R, Fineberg, E, Evans, DG, Lalloo, F, Hansen, TVO , Ejlertsen, B , Gerdes, A-M & SWE-BRCA 2012, 'A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers', Cancer Epidemiology, Biomarkers & Prevention, vol. 21, no. 8, pp. 1362-70. https://doi.org/10.1158/1055-9965.EPI-12-0229

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abstract = "We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.",

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T1 - A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers

AU - Ding, Yuan C

AU - McGuffog, Lesley

AU - Healey, Sue

AU - Friedman, Eitan

AU - Laitman, Yael

AU - Paluch-Shimon, Shani-

AU - Kaufman, Bella

AU - Liljegren, Annelie

AU - Lindblom, Annika

AU - Olsson, Håkan

AU - Kristoffersson, Ulf

AU - Stenmark-Askmalm, Marie

AU - Melin, Beatrice

AU - Domchek, Susan M

AU - Nathanson, Katherine L

AU - Rebbeck, Timothy R

AU - Jakubowska, Anna

AU - Lubinski, Jan

AU - Jaworska, Katarzyna

AU - Durda, Katarzyna

AU - Gronwald, Jacek

AU - Huzarski, Tomasz

AU - Cybulski, Cezary

AU - Byrski, Tomasz

AU - Osorio, Ana

AU - Cajal, Teresa Ramóny

AU - Stavropoulou, Alexandra V

AU - Benítez, Javier

AU - Hamann, Ute

AU - Rookus, Matti

AU - Aalfs, Cora M

AU - de Lange, Judith L

AU - Meijers-Heijboer, Hanne E J

AU - Oosterwijk, Jan C

AU - van Asperen, Christi J

AU - Gómez García, Encarna B

AU - Hoogerbrugge, Nicoline

AU - Jager, Agnes

AU - van der Luijt, Rob B

AU - Easton, Douglas F

AU - Peock, Susan

AU - Frost, Debra

AU - Ellis, Steve D

AU - Platte, Radka

AU - Fineberg, Elena

AU - Evans, D Gareth

AU - Lalloo, Fiona

AU - Hansen, Thomas V O

AU - Ejlertsen, Bent

AU - Gerdes, Anne-Marie

AU - SWE-BRCA

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AB - We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.

U2 - 10.1158/1055-9965.EPI-12-0229

DO - 10.1158/1055-9965.EPI-12-0229

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JO - Cancer Epidemiology, Biomarkers & Prevention

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IS - 8

ER -

A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers

Abstract

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