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The Capital Region of Denmark - a part of Copenhagen University Hospital
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A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma-a case report

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  1. Proposal of a new grading system for meningioma resection: the Copenhagen Protocol

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  2. Burr hole craniostomy versus minicraniotomy in chronic subdural hematoma: a comparative cohort study

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  3. In response to: "Effective prophylaxis regimens against Cutibacterium acnes in Neurosurgery" by d'Alessandris et al

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  4. Lumbar puncture position influences intracranial pressure

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  1. Constitutional POLE variants causing a phenotype reminiscent of constitutional mismatch repair deficiency

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Proposal of a new grading system for meningioma resection: the Copenhagen Protocol

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Diagnostic Accuracy and Clinical Impact of [ 18F]FET PET in Childhood CNS tumors

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Meningiomas are benign lesion although anot insignificant number experiences recurrences despite Simpson grade 1 removal. FG001 is a compound with a fluorophore (ICG) that binds to a urokinase-type plasminogen activator receptor (uPAR) and is currently investigated at our institution in a first-in-human trial. The patient presented with a plausible malignant glioma but proved to be a grade 1 meningioma. FG001 could delineated the tumor not only on the surface but supplementary in the cavity to remove safely the dural attachment. We present FG001 as a new promising tool for improved surgical radicality beyond the intended indication, provided that a prospective validation in a consecutive meningioma cohort demonstrates similar results.

Original languageEnglish
JournalActa Neurochirurgica
Volume164
Issue number1
Pages (from-to)267-271
Number of pages5
ISSN0001-6268
DOIs
Publication statusPublished - Jan 2022

Bibliographical note

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

    Research areas

  • Brain surgery, FG001, Fluorescense, Meningiomas, Radicality, uPar

ID: 68903815