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A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions

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Harvard

Barbateskovic, M, Koster, TM, Eck, RJ, Maagaard, M, Afshari, A, Blokzijl, F, Cronhjort, M, Dieperink, W, Fabritius, ML, Feinberg, J, French, C, Gareb, B, Geisler, A, Granholm, A, Hiemstra, B, Hu, R, Imberger, G, Jensen, BT, Jonsson, AB, Karam, O, Kong, DZ, Korang, SK, Koster, G, Lai, B, Liang, N, Lundstrøm, LH, Marker, S, Meyhoff, T, Nielsen, EE, Nørskov, AK, Munch, MW, Risom, EC, Rygård, SL, Safi, S, Sethi, N, Sjövall, F, Lauridsen, SV, van Bakelen, N, Volbeda, M, van der Horst, I, Gluud, C, Perner, A, Møller, MH, Keus, F & Wetterslev, J 2021, 'A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions', Journal of Clinical Epidemiology, vol. 135, pp. 29-41. https://doi.org/10.1016/j.jclinepi.2021.01.023

APA

Barbateskovic, M., Koster, T. M., Eck, R. J., Maagaard, M., Afshari, A., Blokzijl, F., Cronhjort, M., Dieperink, W., Fabritius, M. L., Feinberg, J., French, C., Gareb, B., Geisler, A., Granholm, A., Hiemstra, B., Hu, R., Imberger, G., Jensen, B. T., Jonsson, A. B., ... Wetterslev, J. (2021). A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions. Journal of Clinical Epidemiology, 135, 29-41. https://doi.org/10.1016/j.jclinepi.2021.01.023

CBE

MLA

Vancouver

Author

Barbateskovic, M ; Koster, T M ; Eck, R J ; Maagaard, M ; Afshari, A ; Blokzijl, F ; Cronhjort, M ; Dieperink, W ; Fabritius, M L ; Feinberg, J ; French, C ; Gareb, B ; Geisler, A ; Granholm, A ; Hiemstra, B ; Hu, R ; Imberger, G ; Jensen, B T ; Jonsson, A B ; Karam, O ; Kong, D Z ; Korang, S K ; Koster, G ; Lai, B ; Liang, N ; Lundstrøm, L H ; Marker, S ; Meyhoff, T ; Nielsen, E E ; Nørskov, A K ; Munch, M W ; Risom, E C ; Rygård, S L ; Safi, S ; Sethi, N ; Sjövall, F ; Lauridsen, S V ; van Bakelen, N ; Volbeda, M ; van der Horst, Icc ; Gluud, C ; Perner, A ; Møller, M H ; Keus, F ; Wetterslev, J. / A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions. In: Journal of Clinical Epidemiology. 2021 ; Vol. 135. pp. 29-41.

Bibtex

@article{4c1840902636462781dbc8ecce3bca75,
title = "A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions",
abstract = "OBJECTIVE: To develop and validate Clinical Diversity In Meta-analyses (CDIM), a new tool for assessing clinical diversity between trials in meta-analyses of interventions.STUDY DESIGN AND SETTING: The development of CDIM was based on consensus work informed by empirical literature and expertise. We drafted the CDIM tool, refined it, and validated CDIM for interrater scale reliability and agreement in three groups.RESULTS: CDIM measures clinical diversity on a scale that includes four domains with 11 items overall: setting (time of conduct/country development status/units type); population (age; sex; patient inclusion criteria/baseline disease severity, comorbidities); interventions (intervention intensity/strength/duration of intervention; timing; control intervention; cointerventions);and outcome (definition of outcome; timing of outcome assessment). The CDIM is completed in two steps: first two authors independently assess clinical diversity in the four domains. Second, after agreeing upon scores of individual items a consensus score is achieved. Interrater scale reliability and agreement ranged from moderate to almost perfect depending on the type of raters.CONCLUSION: CDIM is the first tool developed for assessing clinical diversity in meta-analyses of interventions. We found CDIM to be a reliable tool for assessing clinical diversity among trials in meta-analysis.",
keywords = "Diversity, Evidence, Heterogeneity, Meta-analysis, Quality, Systematic review, Tool",
author = "M Barbateskovic and Koster, {T M} and Eck, {R J} and M Maagaard and A Afshari and F Blokzijl and M Cronhjort and W Dieperink and Fabritius, {M L} and J Feinberg and C French and B Gareb and A Geisler and A Granholm and B Hiemstra and R Hu and G Imberger and Jensen, {B T} and Jonsson, {A B} and O Karam and Kong, {D Z} and Korang, {S K} and G Koster and B Lai and N Liang and Lundstr{\o}m, {L H} and S Marker and T Meyhoff and Nielsen, {E E} and N{\o}rskov, {A K} and Munch, {M W} and Risom, {E C} and Ryg{\aa}rd, {S L} and S Safi and N Sethi and F Sj{\"o}vall and Lauridsen, {S V} and {van Bakelen}, N and M Volbeda and {van der Horst}, Icc and C Gluud and A Perner and M{\o}ller, {M H} and F Keus and J Wetterslev",
note = "Copyright {\textcopyright} 2021 Elsevier Inc. All rights reserved.",
year = "2021",
month = jul,
doi = "10.1016/j.jclinepi.2021.01.023",
language = "English",
volume = "135",
pages = "29--41",
journal = "Journal of Clinical Epidemiology",
issn = "0895-4356",
publisher = "Elsevier Inc",

}

RIS

TY - JOUR

T1 - A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions

AU - Barbateskovic, M

AU - Koster, T M

AU - Eck, R J

AU - Maagaard, M

AU - Afshari, A

AU - Blokzijl, F

AU - Cronhjort, M

AU - Dieperink, W

AU - Fabritius, M L

AU - Feinberg, J

AU - French, C

AU - Gareb, B

AU - Geisler, A

AU - Granholm, A

AU - Hiemstra, B

AU - Hu, R

AU - Imberger, G

AU - Jensen, B T

AU - Jonsson, A B

AU - Karam, O

AU - Kong, D Z

AU - Korang, S K

AU - Koster, G

AU - Lai, B

AU - Liang, N

AU - Lundstrøm, L H

AU - Marker, S

AU - Meyhoff, T

AU - Nielsen, E E

AU - Nørskov, A K

AU - Munch, M W

AU - Risom, E C

AU - Rygård, S L

AU - Safi, S

AU - Sethi, N

AU - Sjövall, F

AU - Lauridsen, S V

AU - van Bakelen, N

AU - Volbeda, M

AU - van der Horst, Icc

AU - Gluud, C

AU - Perner, A

AU - Møller, M H

AU - Keus, F

AU - Wetterslev, J

N1 - Copyright © 2021 Elsevier Inc. All rights reserved.

PY - 2021/7

Y1 - 2021/7

N2 - OBJECTIVE: To develop and validate Clinical Diversity In Meta-analyses (CDIM), a new tool for assessing clinical diversity between trials in meta-analyses of interventions.STUDY DESIGN AND SETTING: The development of CDIM was based on consensus work informed by empirical literature and expertise. We drafted the CDIM tool, refined it, and validated CDIM for interrater scale reliability and agreement in three groups.RESULTS: CDIM measures clinical diversity on a scale that includes four domains with 11 items overall: setting (time of conduct/country development status/units type); population (age; sex; patient inclusion criteria/baseline disease severity, comorbidities); interventions (intervention intensity/strength/duration of intervention; timing; control intervention; cointerventions);and outcome (definition of outcome; timing of outcome assessment). The CDIM is completed in two steps: first two authors independently assess clinical diversity in the four domains. Second, after agreeing upon scores of individual items a consensus score is achieved. Interrater scale reliability and agreement ranged from moderate to almost perfect depending on the type of raters.CONCLUSION: CDIM is the first tool developed for assessing clinical diversity in meta-analyses of interventions. We found CDIM to be a reliable tool for assessing clinical diversity among trials in meta-analysis.

AB - OBJECTIVE: To develop and validate Clinical Diversity In Meta-analyses (CDIM), a new tool for assessing clinical diversity between trials in meta-analyses of interventions.STUDY DESIGN AND SETTING: The development of CDIM was based on consensus work informed by empirical literature and expertise. We drafted the CDIM tool, refined it, and validated CDIM for interrater scale reliability and agreement in three groups.RESULTS: CDIM measures clinical diversity on a scale that includes four domains with 11 items overall: setting (time of conduct/country development status/units type); population (age; sex; patient inclusion criteria/baseline disease severity, comorbidities); interventions (intervention intensity/strength/duration of intervention; timing; control intervention; cointerventions);and outcome (definition of outcome; timing of outcome assessment). The CDIM is completed in two steps: first two authors independently assess clinical diversity in the four domains. Second, after agreeing upon scores of individual items a consensus score is achieved. Interrater scale reliability and agreement ranged from moderate to almost perfect depending on the type of raters.CONCLUSION: CDIM is the first tool developed for assessing clinical diversity in meta-analyses of interventions. We found CDIM to be a reliable tool for assessing clinical diversity among trials in meta-analysis.

KW - Diversity

KW - Evidence

KW - Heterogeneity

KW - Meta-analysis

KW - Quality

KW - Systematic review

KW - Tool

UR - http://www.scopus.com/inward/record.url?scp=85102038804&partnerID=8YFLogxK

U2 - 10.1016/j.jclinepi.2021.01.023

DO - 10.1016/j.jclinepi.2021.01.023

M3 - Journal article

C2 - 33561529

VL - 135

SP - 29

EP - 41

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

SN - 0895-4356

ER -

ID: 62238157