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A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy

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  • Mariangela Peruzzi
  • Leonardo De Luca
  • Henrik S Thomsen
  • Enrico Romagnoli
  • Fabrizio D'Ascenzo
  • Massimo Mancone
  • Gennaro Sardella
  • Luigi Lucisano
  • Antonio Abbate
  • Giacomo Frati
  • Giuseppe Biondi-Zoccai
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Contrast-induced nephropathy is a common complication of iodinated contrast administration. Statins may reduce the risk of contrast-induced nephropathy, but data remain inconclusive. We summarized the evidence based on statins for the prevention of contrast-induced nephropathy with a network meta-analysis. Randomized trials focusing on statins were searched and pooled with random-effect odds ratios. A total of 14 trials (6,160 patients) were included, focusing on atorvastatin (high/low dose), rosuvastatin (high dose), simvastatin (high/low dose), and placebo or no statin therapy before contrast administration. The risk of contrast-induced nephropathy was reduced by atorvastatin high dose and rosuvastatin high dose, with no difference between these two agents. Results for atorvastatin low dose and simvastatin (high/low dose) in comparison to placebo were inconclusive. Atorvastatin and rosuvastatin administered at high doses and before iodinated contrast administration have a consistent and beneficial preventive effect on contrast-induced nephropathy and may actually halve its incidence.

Original languageEnglish
JournalBioMed Research International
Volume2014
Pages (from-to)213239
DOIs
Publication statusPublished - 2014

ID: 44856310