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A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

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Harvard

Escala-Garcia, M, Abraham, J, Andrulis, IL, Anton-Culver, H, Arndt, V, Ashworth, A, Auer, PL, Auvinen, P, Beckmann, MW, Beesley, J, Behrens, S, Benitez, J, Bermisheva, M, Blomqvist, C, Blot, W, Bogdanova, NV, Bojesen, SE, Bolla, MK, Børresen-Dale, A-L, Brauch, H, Brenner, H, Brucker, SY, Burwinkel, B, Caldas, C, Canzian, F, Chang-Claude, J, Chanock, SJ, Chin, S-F, Clarke, CL, Couch, FJ, Cox, A, Cross, SS, Czene, K, Daly, MB, Dennis, J, Devilee, P, Dunn, JA, Dunning, AM, Dwek, M, Earl, HM, Eccles, DM, Eliassen, AH, Ellberg, C, Evans, DG, Fasching, PA, Figueroa, J, Flyger, H, Gago-Dominguez, M, Gapstur, SM, García-Closas, M, García-Sáenz, JA, Gaudet, MM, George, A, Giles, GG, Goldgar, DE, González-Neira, A, Grip, M, Guénel, P, Guo, Q, Haiman, CA, Håkansson, N, Hamann, U, Harrington, PA, Hiller, L, Hooning, MJ, Hopper, JL, Howell, A, Huang, C-S, Huang, G, Hunter, DJ, Jakubowska, A, John, EM, Kaaks, R, Kapoor, PM, Keeman, R, Kitahara, CM, Koppert, LB, Kraft, P, Kristensen, VN, Lambrechts, D, Le Marchand, L, Lejbkowicz, F, Lindblom, A, Lubiński, J, Mannermaa, A, Manoochehri, M, Manoukian, S, Margolin, S, Martinez, ME, Maurer, T, Mavroudis, D, Meindl, A, Milne, RL, Mulligan, AM, Neuhausen, SL, Nevanlinna, H, Newman, WG, Olshan, AF, Olson, JE, Olsson, H, Orr, N, Peterlongo, P, Petridis, C, Prentice, RL, Presneau, N, Punie, K, Ramachandran, D, Rennert, G, Romero, A, Sachchithananthan, M, Saloustros, E, Sawyer, EJ, Schmutzler, RK, Schwentner, L, Scott, C, Simard, J, Sohn, C, Southey, MC, Swerdlow, AJ, Tamimi, RM, Tapper, WJ, Teixeira, MR, Terry, MB, Thorne, H, Tollenaar, RAEM, Tomlinson, I, Troester, MA, Truong, T, Turnbull, C, Vachon, CM, van der Kolk, LE, Wang, Q, Winqvist, R, Wolk, A, Yang, XR, Ziogas, A, Pharoah, PDP, Hall, P, Wessels, LFA, Chenevix-Trench, G, Bader, GD, Dörk, T, Easton, DF, Canisius, S & Schmidt, MK 2020, 'A network analysis to identify mediators of germline-driven differences in breast cancer prognosis' Nature Communications, vol. 11, no. 1, pp. 312. https://doi.org/10.1038/s41467-019-14100-6

APA

Escala-Garcia, M., Abraham, J., Andrulis, I. L., Anton-Culver, H., Arndt, V., Ashworth, A., ... Schmidt, M. K. (2020). A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Nature Communications, 11(1), 312. https://doi.org/10.1038/s41467-019-14100-6

CBE

Escala-Garcia M, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Ashworth A, Auer PL, Auvinen P, Beckmann MW, Beesley J, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Blot W, Bogdanova NV, Bojesen SE, Bolla MK, Børresen-Dale A-L, Brauch H, Brenner H, Brucker SY, Burwinkel B, Caldas C, Canzian F, Chang-Claude J, Chanock SJ, Chin S-F, Clarke CL, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Dennis J, Devilee P, Dunn JA, Dunning AM, Dwek M, Earl HM, Eccles DM, Eliassen AH, Ellberg C, Evans DG, Fasching PA, Figueroa J, Flyger H, Gago-Dominguez M, Gapstur SM, García-Closas M, García-Sáenz JA, Gaudet MM, George A, Giles GG, Goldgar DE, González-Neira A, Grip M, Guénel P, Guo Q, Haiman CA, Håkansson N, Hamann U, Harrington PA, Hiller L, Hooning MJ, Hopper JL, Howell A, Huang C-S, Huang G, Hunter DJ, Jakubowska A, John EM, Kaaks R, Kapoor PM, Keeman R, Kitahara CM, Koppert LB, Kraft P, Kristensen VN, Lambrechts D, Le Marchand L, Lejbkowicz F, Lindblom A, Lubiński J, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Martinez ME, Maurer T, Mavroudis D, Meindl A, Milne RL, Mulligan AM, Neuhausen SL, Nevanlinna H, Newman WG, Olshan AF, Olson JE, Olsson H, Orr N, Peterlongo P, Petridis C, Prentice RL, Presneau N, Punie K, Ramachandran D, Rennert G, Romero A, Sachchithananthan M, Saloustros E, Sawyer EJ, Schmutzler RK, Schwentner L, Scott C, Simard J, Sohn C, Southey MC, Swerdlow AJ, Tamimi RM, Tapper WJ, Teixeira MR, Terry MB, Thorne H, Tollenaar RAEM, Tomlinson I, Troester MA, Truong T, Turnbull C, Vachon CM, van der Kolk LE, Wang Q, Winqvist R, Wolk A, Yang XR, Ziogas A, Pharoah PDP, Hall P, Wessels LFA, Chenevix-Trench G, Bader GD, Dörk T, Easton DF, Canisius S, Schmidt MK. 2020. A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Nature Communications. 11(1):312. https://doi.org/10.1038/s41467-019-14100-6

MLA

Vancouver

Escala-Garcia M, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Ashworth A et al. A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Nature Communications. 2020 Jan 16;11(1):312. https://doi.org/10.1038/s41467-019-14100-6

Author

Escala-Garcia, Maria ; Abraham, Jean ; Andrulis, Irene L ; Anton-Culver, Hoda ; Arndt, Volker ; Ashworth, Alan ; Auer, Paul L ; Auvinen, Päivi ; Beckmann, Matthias W ; Beesley, Jonathan ; Behrens, Sabine ; Benitez, Javier ; Bermisheva, Marina ; Blomqvist, Carl ; Blot, William ; Bogdanova, Natalia V ; Bojesen, Stig E ; Bolla, Manjeet K ; Børresen-Dale, Anne-Lise ; Brauch, Hiltrud ; Brenner, Hermann ; Brucker, Sara Y ; Burwinkel, Barbara ; Caldas, Carlos ; Canzian, Federico ; Chang-Claude, Jenny ; Chanock, Stephen J ; Chin, Suet-Feung ; Clarke, Christine L ; Couch, Fergus J ; Cox, Angela ; Cross, Simon S ; Czene, Kamila ; Daly, Mary B ; Dennis, Joe ; Devilee, Peter ; Dunn, Janet A ; Dunning, Alison M ; Dwek, Miriam ; Earl, Helena M ; Eccles, Diana M ; Eliassen, A Heather ; Ellberg, Carolina ; Evans, D Gareth ; Fasching, Peter A ; Figueroa, Jonine ; Flyger, Henrik ; Gago-Dominguez, Manuela ; Gapstur, Susan M ; García-Closas, Montserrat ; García-Sáenz, José A ; Gaudet, Mia M ; George, Angela ; Giles, Graham G ; Goldgar, David E ; González-Neira, Anna ; Grip, Mervi ; Guénel, Pascal ; Guo, Qi ; Haiman, Christopher A ; Håkansson, Niclas ; Hamann, Ute ; Harrington, Patricia A ; Hiller, Louise ; Hooning, Maartje J ; Hopper, John L ; Howell, Anthony ; Huang, Chiun-Sheng ; Huang, Guanmengqian ; Hunter, David J ; Jakubowska, Anna ; John, Esther M ; Kaaks, Rudolf ; Kapoor, Pooja Middha ; Keeman, Renske ; Kitahara, Cari M ; Koppert, Linetta B ; Kraft, Peter ; Kristensen, Vessela N ; Lambrechts, Diether ; Le Marchand, Loic ; Lejbkowicz, Flavio ; Lindblom, Annika ; Lubiński, Jan ; Mannermaa, Arto ; Manoochehri, Mehdi ; Manoukian, Siranoush ; Margolin, Sara ; Martinez, Maria Elena ; Maurer, Tabea ; Mavroudis, Dimitrios ; Meindl, Alfons ; Milne, Roger L ; Mulligan, Anna Marie ; Neuhausen, Susan L ; Nevanlinna, Heli ; Newman, William G ; Olshan, Andrew F ; Olson, Janet E ; Olsson, Håkan ; Orr, Nick ; Peterlongo, Paolo ; Petridis, Christos ; Prentice, Ross L ; Presneau, Nadege ; Punie, Kevin ; Ramachandran, Dhanya ; Rennert, Gad ; Romero, Atocha ; Sachchithananthan, Mythily ; Saloustros, Emmanouil ; Sawyer, Elinor J ; Schmutzler, Rita K ; Schwentner, Lukas ; Scott, Christopher ; Simard, Jacques ; Sohn, Christof ; Southey, Melissa C ; Swerdlow, Anthony J ; Tamimi, Rulla M ; Tapper, William J ; Teixeira, Manuel R ; Terry, Mary Beth ; Thorne, Heather ; Tollenaar, Rob A E M ; Tomlinson, Ian ; Troester, Melissa A ; Truong, Thérèse ; Turnbull, Clare ; Vachon, Celine M ; van der Kolk, Lizet E ; Wang, Qin ; Winqvist, Robert ; Wolk, Alicja ; Yang, Xiaohong R ; Ziogas, Argyrios ; Pharoah, Paul D P ; Hall, Per ; Wessels, Lodewyk F A ; Chenevix-Trench, Georgia ; Bader, Gary D ; Dörk, Thilo ; Easton, Douglas F ; Canisius, Sander ; Schmidt, Marjanka K. / A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. In: Nature Communications. 2020 ; Vol. 11, No. 1. pp. 312.

Bibtex

@article{0b6dfc1c656f406b886eb82f893682c6,
title = "A network analysis to identify mediators of germline-driven differences in breast cancer prognosis",
abstract = "Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.",
author = "Maria Escala-Garcia and Jean Abraham and Andrulis, {Irene L} and Hoda Anton-Culver and Volker Arndt and Alan Ashworth and Auer, {Paul L} and P{\"a}ivi Auvinen and Beckmann, {Matthias W} and Jonathan Beesley and Sabine Behrens and Javier Benitez and Marina Bermisheva and Carl Blomqvist and William Blot and Bogdanova, {Natalia V} and Bojesen, {Stig E} and Bolla, {Manjeet K} and Anne-Lise B{\o}rresen-Dale and Hiltrud Brauch and Hermann Brenner and Brucker, {Sara Y} and Barbara Burwinkel and Carlos Caldas and Federico Canzian and Jenny Chang-Claude and Chanock, {Stephen J} and Suet-Feung Chin and Clarke, {Christine L} and Couch, {Fergus J} and Angela Cox and Cross, {Simon S} and Kamila Czene and Daly, {Mary B} and Joe Dennis and Peter Devilee and Dunn, {Janet A} and Dunning, {Alison M} and Miriam Dwek and Earl, {Helena M} and Eccles, {Diana M} and Eliassen, {A Heather} and Carolina Ellberg and Evans, {D Gareth} and Fasching, {Peter A} and Jonine Figueroa and Henrik Flyger and Manuela Gago-Dominguez and Gapstur, {Susan M} and Montserrat Garc{\'i}a-Closas and Garc{\'i}a-S{\'a}enz, {Jos{\'e} A} and Gaudet, {Mia M} and Angela George and Giles, {Graham G} and Goldgar, {David E} and Anna Gonz{\'a}lez-Neira and Mervi Grip and Pascal Gu{\'e}nel and Qi Guo and Haiman, {Christopher A} and Niclas H{\aa}kansson and Ute Hamann and Harrington, {Patricia A} and Louise Hiller and Hooning, {Maartje J} and Hopper, {John L} and Anthony Howell and Chiun-Sheng Huang and Guanmengqian Huang and Hunter, {David J} and Anna Jakubowska and John, {Esther M} and Rudolf Kaaks and Kapoor, {Pooja Middha} and Renske Keeman and Kitahara, {Cari M} and Koppert, {Linetta B} and Peter Kraft and Kristensen, {Vessela N} and Diether Lambrechts and {Le Marchand}, Loic and Flavio Lejbkowicz and Annika Lindblom and Jan Lubiński and Arto Mannermaa and Mehdi Manoochehri and Siranoush Manoukian and Sara Margolin and Martinez, {Maria Elena} and Tabea Maurer and Dimitrios Mavroudis and Alfons Meindl and Milne, {Roger L} and Mulligan, {Anna Marie} and Neuhausen, {Susan L} and Heli Nevanlinna and Newman, {William G} and Olshan, {Andrew F} and Olson, {Janet E} and H{\aa}kan Olsson and Nick Orr and Paolo Peterlongo and Christos Petridis and Prentice, {Ross L} and Nadege Presneau and Kevin Punie and Dhanya Ramachandran and Gad Rennert and Atocha Romero and Mythily Sachchithananthan and Emmanouil Saloustros and Sawyer, {Elinor J} and Schmutzler, {Rita K} and Lukas Schwentner and Christopher Scott and Jacques Simard and Christof Sohn and Southey, {Melissa C} and Swerdlow, {Anthony J} and Tamimi, {Rulla M} and Tapper, {William J} and Teixeira, {Manuel R} and Terry, {Mary Beth} and Heather Thorne and Tollenaar, {Rob A E M} and Ian Tomlinson and Troester, {Melissa A} and Th{\'e}r{\`e}se Truong and Clare Turnbull and Vachon, {Celine M} and {van der Kolk}, {Lizet E} and Qin Wang and Robert Winqvist and Alicja Wolk and Yang, {Xiaohong R} and Argyrios Ziogas and Pharoah, {Paul D P} and Per Hall and Wessels, {Lodewyk F A} and Georgia Chenevix-Trench and Bader, {Gary D} and Thilo D{\"o}rk and Easton, {Douglas F} and Sander Canisius and Schmidt, {Marjanka K}",
year = "2020",
month = "1",
day = "16",
doi = "10.1038/s41467-019-14100-6",
language = "English",
volume = "11",
pages = "312",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

AU - Escala-Garcia, Maria

AU - Abraham, Jean

AU - Andrulis, Irene L

AU - Anton-Culver, Hoda

AU - Arndt, Volker

AU - Ashworth, Alan

AU - Auer, Paul L

AU - Auvinen, Päivi

AU - Beckmann, Matthias W

AU - Beesley, Jonathan

AU - Behrens, Sabine

AU - Benitez, Javier

AU - Bermisheva, Marina

AU - Blomqvist, Carl

AU - Blot, William

AU - Bogdanova, Natalia V

AU - Bojesen, Stig E

AU - Bolla, Manjeet K

AU - Børresen-Dale, Anne-Lise

AU - Brauch, Hiltrud

AU - Brenner, Hermann

AU - Brucker, Sara Y

AU - Burwinkel, Barbara

AU - Caldas, Carlos

AU - Canzian, Federico

AU - Chang-Claude, Jenny

AU - Chanock, Stephen J

AU - Chin, Suet-Feung

AU - Clarke, Christine L

AU - Couch, Fergus J

AU - Cox, Angela

AU - Cross, Simon S

AU - Czene, Kamila

AU - Daly, Mary B

AU - Dennis, Joe

AU - Devilee, Peter

AU - Dunn, Janet A

AU - Dunning, Alison M

AU - Dwek, Miriam

AU - Earl, Helena M

AU - Eccles, Diana M

AU - Eliassen, A Heather

AU - Ellberg, Carolina

AU - Evans, D Gareth

AU - Fasching, Peter A

AU - Figueroa, Jonine

AU - Flyger, Henrik

AU - Gago-Dominguez, Manuela

AU - Gapstur, Susan M

AU - García-Closas, Montserrat

AU - García-Sáenz, José A

AU - Gaudet, Mia M

AU - George, Angela

AU - Giles, Graham G

AU - Goldgar, David E

AU - González-Neira, Anna

AU - Grip, Mervi

AU - Guénel, Pascal

AU - Guo, Qi

AU - Haiman, Christopher A

AU - Håkansson, Niclas

AU - Hamann, Ute

AU - Harrington, Patricia A

AU - Hiller, Louise

AU - Hooning, Maartje J

AU - Hopper, John L

AU - Howell, Anthony

AU - Huang, Chiun-Sheng

AU - Huang, Guanmengqian

AU - Hunter, David J

AU - Jakubowska, Anna

AU - John, Esther M

AU - Kaaks, Rudolf

AU - Kapoor, Pooja Middha

AU - Keeman, Renske

AU - Kitahara, Cari M

AU - Koppert, Linetta B

AU - Kraft, Peter

AU - Kristensen, Vessela N

AU - Lambrechts, Diether

AU - Le Marchand, Loic

AU - Lejbkowicz, Flavio

AU - Lindblom, Annika

AU - Lubiński, Jan

AU - Mannermaa, Arto

AU - Manoochehri, Mehdi

AU - Manoukian, Siranoush

AU - Margolin, Sara

AU - Martinez, Maria Elena

AU - Maurer, Tabea

AU - Mavroudis, Dimitrios

AU - Meindl, Alfons

AU - Milne, Roger L

AU - Mulligan, Anna Marie

AU - Neuhausen, Susan L

AU - Nevanlinna, Heli

AU - Newman, William G

AU - Olshan, Andrew F

AU - Olson, Janet E

AU - Olsson, Håkan

AU - Orr, Nick

AU - Peterlongo, Paolo

AU - Petridis, Christos

AU - Prentice, Ross L

AU - Presneau, Nadege

AU - Punie, Kevin

AU - Ramachandran, Dhanya

AU - Rennert, Gad

AU - Romero, Atocha

AU - Sachchithananthan, Mythily

AU - Saloustros, Emmanouil

AU - Sawyer, Elinor J

AU - Schmutzler, Rita K

AU - Schwentner, Lukas

AU - Scott, Christopher

AU - Simard, Jacques

AU - Sohn, Christof

AU - Southey, Melissa C

AU - Swerdlow, Anthony J

AU - Tamimi, Rulla M

AU - Tapper, William J

AU - Teixeira, Manuel R

AU - Terry, Mary Beth

AU - Thorne, Heather

AU - Tollenaar, Rob A E M

AU - Tomlinson, Ian

AU - Troester, Melissa A

AU - Truong, Thérèse

AU - Turnbull, Clare

AU - Vachon, Celine M

AU - van der Kolk, Lizet E

AU - Wang, Qin

AU - Winqvist, Robert

AU - Wolk, Alicja

AU - Yang, Xiaohong R

AU - Ziogas, Argyrios

AU - Pharoah, Paul D P

AU - Hall, Per

AU - Wessels, Lodewyk F A

AU - Chenevix-Trench, Georgia

AU - Bader, Gary D

AU - Dörk, Thilo

AU - Easton, Douglas F

AU - Canisius, Sander

AU - Schmidt, Marjanka K

PY - 2020/1/16

Y1 - 2020/1/16

N2 - Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.

AB - Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.

U2 - 10.1038/s41467-019-14100-6

DO - 10.1038/s41467-019-14100-6

M3 - Journal article

VL - 11

SP - 312

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

ER -

ID: 59352096