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A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark

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  • Anna Irene Vedel Sørensen
  • Lampros Spiliopoulos
  • Peter Bager
  • Nete Munk Nielsen
  • Jørgen Vinsløv Hansen
  • Anders Koch
  • Inger Kristine Meder
  • Steen Ethelberg
  • Anders Hviid
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A considerable number of individuals infected with SARS-CoV-2 continue to experience symptoms after the acute phase. Here, we report findings from a nationwide questionnaire study in Denmark including 61,002 RT-PCR confirmed SARS-CoV-2 cases and 91,878 test-negative controls aged 15-years or older. Six to twelve months after the test, the risks of 18 out of 21 symptoms were elevated among test-positives. The largest adjusted risk differences (RD) were observed for dysosmia (RD = 10.92%, 95% CI 10.68-11.21%), dysgeusia (RD = 8.68%, 95% CI 8.43-8.93%), fatigue/exhaustion (RD = 8.43%, 95%CI 8.14-8.74%), dyspnea (RD = 4.87%, 95% CI 4.65-5.09%) and reduced strength in arms/legs (RD = 4.68%, 95% CI 4.45-4.89%). During the period from the test and until completion of the questionnaire, new diagnoses of anxiety (RD = 1.15%, 95% CI 0.95-1.34%) or depression (RD = 1.00%, 95% CI 0.81-1.19%) were also more common among test-positives. Even in a population where the majority of test-positives were not hospitalized, a considerable proportion experiences symptoms up to 12 months after infection. Being female or middle-aged increases risks.

Original languageEnglish
Article number4213
JournalNature Communications
Volume13
Issue number1
Pages (from-to)4213
ISSN2041-1722
DOIs
Publication statusPublished - 21 Jul 2022

Bibliographical note

© 2022. The Author(s).

ID: 79685446