Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Self-reported immunity and opinions on vaccination of hospital personnel among paediatric healthcare workers in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Are refugees arriving in Denmark an under-immunised group for measles? A cross-sectional serology study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Smallpox and BCG vaccination in childhood and cutaneous malignant melanoma in Danish adults followed from 18 to 49 years

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Adverse pregnancy outcomes and infant mortality after quadrivalent HPV vaccination during pregnancy

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Next Generation Sequencing-Based Fetal ABO Blood Group Prediction by Analysis of Cell-Free DNA from Maternal Plasma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Targeted Rhesus immunoglobulin for RhD negative women undergoing an induced abortion: a clinical pilot study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Blood group genotyping of blood donors: validation of a highly accurate routine method

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Effective control and eventual eradication of malaria drives the imperative need for clinical development of a malaria vaccine. Asexual parasite forms are responsible for clinical disease and death while apathogenic gametocytes are responsible for transmission from man to mosquito. Vaccines that combine antigens from both stages may provide direct protection and indirect benefit by reducing the force of infection. We constructed a chimeric antigen composed of a fragment of the Plasmodium falciparum (Pf) glutamate-rich protein fused in frame to a correctly folded fragment of Pfs48/45. The chimera was produced in Lactococcus lactis and induced robust antibody responses in rodents to the individual components. Specific antibodies showed strong transmission blocking activity against multiple Pf-strains in the standard membrane feeding assay and functional activity against asexual stages in the antibody dependent cellular inhibition assay. The combined data provide a strong rationale for entering the next phase of clinical grade production and testing.

Original languageEnglish
JournalVaccine
Volume32
Issue number22
Pages (from-to)2623-30
Number of pages8
ISSN0264-410X
DOIs
Publication statusPublished - 7 May 2014

    Research areas

  • Animals, Anopheles, Antibodies, Protozoan, Antibody Formation, Immune Sera, Immunoglobulin G, Malaria Vaccines, Malaria, Falciparum, Membrane Glycoproteins, Plasmodium falciparum, Protozoan Proteins, Rats, Wistar, Recombinant Proteins, Vaccines, Subunit

ID: 44941725