Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Author Correction: Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Combined burden and functional impact tests for cancer driver discovery using DriverPower

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Cochlear MRI Signal Change Following Vestibular Schwannoma Resection Depends on Surgical Approach

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association of SLC26A4 mutations, morphology, and hearing in pendred syndrome and NSEVA

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Knogleforankrede høreapparater og aktive mellemøreimplantater

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Alfred L Nuttall
  • Anthony J Ricci
  • George Burwood
  • James M Harte
  • Stefan Stenfelt
  • Per Cayé-Thomasen
  • Tianying Ren
  • Sripriya Ramamoorthy
  • Yuan Zhang
  • Teresa Wilson
  • Thomas Lunner
  • Brian C J Moore
  • Anders Fridberger
View graph of relations

To understand speech, the slowly varying outline, or envelope, of the acoustic stimulus is used to distinguish words. A small amount of information about the envelope is sufficient for speech recognition, but the mechanism used by the auditory system to extract the envelope is not known. Several different theories have been proposed, including envelope detection by auditory nerve dendrites as well as various mechanisms involving the sensory hair cells. We used recordings from human and animal inner ears to show that the dominant mechanism for envelope detection is distortion introduced by mechanoelectrical transduction channels. This electrical distortion, which is not apparent in the sound-evoked vibrations of the basilar membrane, tracks the envelope, excites the auditory nerve, and transmits information about the shape of the envelope to the brain.

Original languageEnglish
JournalNature Communications
Volume9
Issue number1
Pages (from-to)4175
ISSN2041-1723
DOIs
Publication statusPublished - 9 Oct 2018

    Research areas

  • Acoustic Stimulation, Adult, Animals, Basilar Membrane/physiology, Biomechanical Phenomena, Cochlea/physiology, Electricity, Female, Hearing/physiology, Humans, Male, Middle Aged, Organ of Corti/physiology, Rats, Sound

ID: 56132608