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A matter of balance: role of neurexin and neuroligin at the synapse

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  1. Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS

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  2. The Top 5 Neurotransmitters from a Clinical Neurologist's Perspective

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  3. Acute hyperammonemia and systemic inflammation is associated with increased extracellular brain adenosine in rats: a biosensor study

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  4. Functional recovery of regenerating motor axons is delayed in mice heterozygously deficient for the myelin protein P(0) gene

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  5. Screening of Toll-like receptors expression in multiple system atrophy brains

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  1. The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival

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  2. Biglycan is a novel binding partner of fibroblast growth factor receptor 3c (FGFR3c) in the human testis

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  3. Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 "Signalosome"

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  4. Neuroplastin: cell adhesion molecule and signaling receptor

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  5. Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

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Neurexins and neuroligins are synaptic cell adhesion molecules. Neurexins are primary located on the presynaptic membrane, whereas neuroligins are strictly postsynaptic proteins. Since their discovery, the knowledge of neurexins and neuroligins has expanded, implicating them in various neuronal processes, including the differentiation, maturation, stabilization, and plasticity of both inhibitory and excitatory synapses. Here, we review the most recent results regarding the structure and function of these cell adhesion molecules.
Original languageEnglish
JournalNeurochemical Research
Volume38
Issue number6
Pages (from-to)1174-89
Number of pages16
ISSN0364-3190
DOIs
Publication statusPublished - Jun 2013

    Research areas

  • Alternative Splicing, Animals, Cell Adhesion Molecules, Neuronal, Child Development Disorders, Pervasive, GABAergic Neurons, Humans, Nerve Tissue Proteins, Protein Conformation, Schizophrenia, Synapses

ID: 42337000