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The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

A major role for common genetic variation in anxiety disorders

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  • Kirstin L Purves
  • Jonathan R I Coleman
  • Sandra M Meier
  • Christopher Rayner
  • Katrina A S Davis
  • Rosa Cheesman
  • Marie Bækvad-Hansen
  • Anders D Børglum
  • Shing Wan Cho
  • J Jürgen Deckert
  • Héléna A Gaspar
  • Jonas Bybjerg-Grauholm
  • John M Hettema
  • Matthew Hotopf
  • David Hougaard
  • Christopher Hübel
  • Carol Kan
  • Andrew M McIntosh
  • Ole Mors
  • Preben Bo Mortensen
  • Merete Nordentoft
  • Thomas Werge
  • Kristin K Nicodemus
  • Manuel Mattheisen
  • Gerome Breen
  • Thalia C Eley
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Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.

Original languageEnglish
JournalMolecular Psychiatry
ISSN1359-4184
DOIs
Publication statusE-pub ahead of print - 20 Nov 2019

ID: 58440217