Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders

Research output: Contribution to journalJournal articleResearchpeer-review

  1. A narrative review of new treatment options for chronic kidney disease in type 2 diabetes

    Research output: Contribution to journalReviewResearchpeer-review

  2. Troubleshooting in advanced VATS procedures

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Intact transferrin and total plasma glycoprofiling for diagnosis and therapy monitoring in phosphoglucomutase-I deficiency

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lyme Borreliosis and Associations With Mental Disorders and Suicidal Behavior: A Nationwide Danish Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Number of Traumatic brain injuries and temporal associations with depression: A register-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Infections are a major disease burden worldwide. While they are caused by external pathogens, host genetics also plays a part in susceptibility to infections. Past studies have reported diverse associations between human leukocyte antigen (HLA) alleles and infections, but many were limited by small sample sizes and/or focused on only one infection.

METHODS: We performed an immunogenetic association study examining 13 categories of severe infection (bacterial, viral, central nervous system, gastrointestinal, genital, hepatitis, otitis, pregnancy-related, respiratory, sepsis, skin infection, urological and other infections), as well as a phenotype for having any infection, and seven classical HLA loci (HLA-A, B, C, DPB1, DQA1, DQB1 and DRB1). Additionally, we examined associations between infections and specific alleles highlighted in our previous studies of psychiatric disorders and autoimmune disease, as these conditions are known to be linked to infections.

RESULTS: Associations between HLA loci and infections were generally not strong. Highlighted associations included associations between DQB1*0302 and DQB1*0604 and viral infections (P = 0.002835 and P = 0.014332, respectively), DQB1*0503 and sepsis (P = 0.006053), and DQA1*0301 with "other" infections (a category which includes infections not included in our main categories e.g. protozoan infections) (P = 0.000369). Some HLA alleles implicated in autoimmune diseases showed association with susceptibility to infections, but the latter associations were generally weaker, or with opposite trends (in the case of HLA-C alleles, but not with alleles of HLA class II genes). HLA alleles associated with psychiatric disorders did not show association with susceptibility to infections.

CONCLUSIONS: Our results suggest that classical HLA alleles do not play a large role in the etiology of severe infections. The discordant association trends with autoimmune disease for some alleles could contribute to mechanistic theories of disease etiology.

Original languageEnglish
Article number230
JournalJournal of Translational Medicine
Volume19
Issue number1
Pages (from-to)230
ISSN1479-5876
DOIs
Publication statusPublished - Dec 2021

    Research areas

  • Alleles, Gene Frequency, Genetic Predisposition to Disease, HLA-A Antigens/genetics, HLA-DQ beta-Chains/genetics, HLA-DRB1 Chains/genetics, Haplotypes, Humans, Mental Disorders/genetics, Association study, Autoimmune disease, MHC, Infections, Psychiatric disorder, Immunogenetics, HLA

ID: 66788698