Abstract
This paper describes a simple high-performance liquid chromatographic method for the determination of disopyramide and lidocaine simultaneously with their dealkylated metabolites. After basic tert-butyl methyl ether extraction and back-extraction with phosphoric acid, the drugs and their metabolites were injected into a Supelcosil CN column and the absorbance of the eluate was measured at 215 nm. The sensitivity was 0.3 mumol/l and the obtained precision, selectivity and stability during storage were adequate for the performed clinical studies in patients therapeutically treated with disopyramide and/or lidocaine. Some results from the clinical studies are briefly presented.
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Clinical and Laboratory Investigation |
| Volume | 46 |
| Issue number | 7 |
| Pages (from-to) | 623-7 |
| Number of pages | 5 |
| ISSN | 0036-5513 |
| DOIs | |
| Publication status | Published - Nov 1986 |
| Externally published | Yes |
Keywords
- Chromatography, High Pressure Liquid/methods
- Disopyramide/blood
- Humans
- Lidocaine/blood