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A histopathological score on baseline biopsies from elderly donors predicts outcome 1 year after renal transplantation

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@article{e10aaf48d55f40559c57f797154e8d26,
title = "A histopathological score on baseline biopsies from elderly donors predicts outcome 1 year after renal transplantation",
abstract = "Kidneys from elderly deceased patients and otherwise marginal donors may be considered for transplantation and a pretransplantation histopathological score for prediction of postoperative outcome is warranted. In a retrospective design, 29 baseline renal needle biopsies from elderly deceased donors (age: 63 ± 4 years; mean ± SD) were evaluated independently by three pathologists and with ten or more glomeruli and one artery present the biopsy was histopathologically scored (numeric score: 0-12) according to the presence of glomerulosclerosis, tubular atrophy, interstitial fibrosis and increased wall thickness of arteries and/or arterioles. Nineteen renal baseline biopsies from 15 donors (age: 64 ± 10 years) were included and following consensus the histopathological score was 4.3 ± 2.1 (intraclass correlation coefficient: 0.81; confidence interval: 0.66-0.92). The donor organs were used for single renal transplantation (recipient age: 47 ± 3 years). Two grafts were lost after the transplantation. In the remaining 17 recipients the 1-year creatinine clearance (54 ± 6 mL/min) correlated to the baseline histopathological score (r(2) = 0.59; p <0.01). This study demonstrates that in elderly Danish donors a histopathological score on baseline renal needle biopsies, with at least ten glomeruli and one artery present, predicts graft function 1 year after transplantation.",
keywords = "Adult, Age Factors, Aged, Biopsy, Fine-Needle, Denmark, Female, Graft Survival, Histocytochemistry, Humans, Kidney, Kidney Transplantation, Male, Middle Aged, Renal Insufficiency, Retrospective Studies, Tissue Donors, Treatment Outcome",
author = "Toft, {Birgitte G} and Federspiel, {Birgitte H} and S{\o}rensen, {S{\o}ren S} and Per Bagi and Nielsen, {Henning M Bay} and Andersen, {Claus B}",
note = "{\circledC} 2011 The Authors. APMIS {\circledC} 2011 APMIS.",
year = "2012",
doi = "10.1111/j.1600-0463.2011.02824.x",
language = "English",
volume = "120",
pages = "182--6",
journal = "Acta pathologica et microbiologica Scandinavica",
issn = "0365-5555",
publisher = "Wiley-Blackwell Munksgaard",
number = "3",

}

RIS

TY - JOUR

T1 - A histopathological score on baseline biopsies from elderly donors predicts outcome 1 year after renal transplantation

AU - Toft, Birgitte G

AU - Federspiel, Birgitte H

AU - Sørensen, Søren S

AU - Bagi, Per

AU - Nielsen, Henning M Bay

AU - Andersen, Claus B

N1 - © 2011 The Authors. APMIS © 2011 APMIS.

PY - 2012

Y1 - 2012

N2 - Kidneys from elderly deceased patients and otherwise marginal donors may be considered for transplantation and a pretransplantation histopathological score for prediction of postoperative outcome is warranted. In a retrospective design, 29 baseline renal needle biopsies from elderly deceased donors (age: 63 ± 4 years; mean ± SD) were evaluated independently by three pathologists and with ten or more glomeruli and one artery present the biopsy was histopathologically scored (numeric score: 0-12) according to the presence of glomerulosclerosis, tubular atrophy, interstitial fibrosis and increased wall thickness of arteries and/or arterioles. Nineteen renal baseline biopsies from 15 donors (age: 64 ± 10 years) were included and following consensus the histopathological score was 4.3 ± 2.1 (intraclass correlation coefficient: 0.81; confidence interval: 0.66-0.92). The donor organs were used for single renal transplantation (recipient age: 47 ± 3 years). Two grafts were lost after the transplantation. In the remaining 17 recipients the 1-year creatinine clearance (54 ± 6 mL/min) correlated to the baseline histopathological score (r(2) = 0.59; p <0.01). This study demonstrates that in elderly Danish donors a histopathological score on baseline renal needle biopsies, with at least ten glomeruli and one artery present, predicts graft function 1 year after transplantation.

AB - Kidneys from elderly deceased patients and otherwise marginal donors may be considered for transplantation and a pretransplantation histopathological score for prediction of postoperative outcome is warranted. In a retrospective design, 29 baseline renal needle biopsies from elderly deceased donors (age: 63 ± 4 years; mean ± SD) were evaluated independently by three pathologists and with ten or more glomeruli and one artery present the biopsy was histopathologically scored (numeric score: 0-12) according to the presence of glomerulosclerosis, tubular atrophy, interstitial fibrosis and increased wall thickness of arteries and/or arterioles. Nineteen renal baseline biopsies from 15 donors (age: 64 ± 10 years) were included and following consensus the histopathological score was 4.3 ± 2.1 (intraclass correlation coefficient: 0.81; confidence interval: 0.66-0.92). The donor organs were used for single renal transplantation (recipient age: 47 ± 3 years). Two grafts were lost after the transplantation. In the remaining 17 recipients the 1-year creatinine clearance (54 ± 6 mL/min) correlated to the baseline histopathological score (r(2) = 0.59; p <0.01). This study demonstrates that in elderly Danish donors a histopathological score on baseline renal needle biopsies, with at least ten glomeruli and one artery present, predicts graft function 1 year after transplantation.

KW - Adult

KW - Age Factors

KW - Aged

KW - Biopsy, Fine-Needle

KW - Denmark

KW - Female

KW - Graft Survival

KW - Histocytochemistry

KW - Humans

KW - Kidney

KW - Kidney Transplantation

KW - Male

KW - Middle Aged

KW - Renal Insufficiency

KW - Retrospective Studies

KW - Tissue Donors

KW - Treatment Outcome

U2 - 10.1111/j.1600-0463.2011.02824.x

DO - 10.1111/j.1600-0463.2011.02824.x

M3 - Journal article

VL - 120

SP - 182

EP - 186

JO - Acta pathologica et microbiologica Scandinavica

JF - Acta pathologica et microbiologica Scandinavica

SN - 0365-5555

IS - 3

ER -

ID: 36584195