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The Capital Region of Denmark - a part of Copenhagen University Hospital
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A histopathological score on baseline biopsies from elderly donors predicts outcome 1 year after renal transplantation

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Kidneys from elderly deceased patients and otherwise marginal donors may be considered for transplantation and a pretransplantation histopathological score for prediction of postoperative outcome is warranted. In a retrospective design, 29 baseline renal needle biopsies from elderly deceased donors (age: 63 ± 4 years; mean ± SD) were evaluated independently by three pathologists and with ten or more glomeruli and one artery present the biopsy was histopathologically scored (numeric score: 0-12) according to the presence of glomerulosclerosis, tubular atrophy, interstitial fibrosis and increased wall thickness of arteries and/or arterioles. Nineteen renal baseline biopsies from 15 donors (age: 64 ± 10 years) were included and following consensus the histopathological score was 4.3 ± 2.1 (intraclass correlation coefficient: 0.81; confidence interval: 0.66-0.92). The donor organs were used for single renal transplantation (recipient age: 47 ± 3 years). Two grafts were lost after the transplantation. In the remaining 17 recipients the 1-year creatinine clearance (54 ± 6 mL/min) correlated to the baseline histopathological score (r(2) = 0.59; p <0.01). This study demonstrates that in elderly Danish donors a histopathological score on baseline renal needle biopsies, with at least ten glomeruli and one artery present, predicts graft function 1 year after transplantation.
Original languageEnglish
JournalAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Volume120
Issue number3
Pages (from-to)182-6
Number of pages5
ISSN0903-4641
DOIs
Publication statusPublished - 2012

    Research areas

  • Adult, Age Factors, Aged, Biopsy, Fine-Needle, Denmark, Female, Graft Survival, Histocytochemistry, Humans, Kidney, Kidney Transplantation, Male, Middle Aged, Renal Insufficiency, Retrospective Studies, Tissue Donors, Treatment Outcome

ID: 36584195