A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients

462 Citations (Scopus)

Abstract

To investigate the association between markers of acute endothelial glycocalyx degradation, inflammation, coagulopathy, and mortality after trauma.
Original languageEnglish
JournalAnnals of Surgery
Volume254
Issue number2
Pages (from-to)194-200
Number of pages7
ISSN0003-4932
DOIs
Publication statusPublished - 1 Aug 2011

Keywords

  • Adult
  • Biological Markers
  • Cohort Studies
  • Endothelium, Vascular
  • Epinephrine
  • Female
  • Fibrin Fibrinogen Degradation Products
  • Fibrinolysis
  • Follow-Up Studies
  • Glycocalyx
  • HMGB1 Protein
  • Histones
  • Hospital Mortality
  • Humans
  • Injury Severity Score
  • Interleukin-10
  • Interleukin-6
  • Male
  • Middle Aged
  • Norepinephrine
  • Patient Admission
  • Prospective Studies
  • Protein C
  • Shock, Hemorrhagic
  • Survival Analysis
  • Syndecan-1
  • Systemic Inflammatory Response Syndrome
  • Thrombomodulin
  • Tissue Plasminogen Activator
  • Urokinase-Type Plasminogen Activator
  • Wounds and Injuries

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