Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A hierarchy of patient-reported outcomes for meta-analysis of knee osteoarthritis trials: empirical evidence from a survey of high impact journals

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Adherence to methotrexate in rheumatoid arthritis: a danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Antibodies to infliximab and adalimumab in patients with rheumatoid arthritis in clinical remission: a cross-sectional study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Serum urate as a proposed surrogate outcome measure in gout trials: From the OMERACT working group

    Research output: Contribution to journalReviewResearchpeer-review

  3. The evolution of instrument selection for inclusion in core outcome sets at OMERACT: Filter 2.2

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Objectives. To develop a prioritised list based on responsiveness for extracting patient-reported outcomes (PROs) measuring pain and disability for performing meta-analyses in knee osteoarthritis (OA). Methods. A systematic search was conducted in 20 highest impact factor general and rheumatology journals chosen a priori. Eligible studies were randomised controlled trials, using two or more PROs measuring pain and/or disability. Results. A literature search identified 402 publications and 38 trials were included, resulting in 54 randomised comparisons. Thirty-five trials had sufficient data on pain and 15 trials on disability. The WOMAC "pain" and "function" subscales were the most responsive composite scores. The following list was developed. Pain: (1) WOMAC "pain" subscale, (2) pain during activity (VAS), (3) pain during walking (VAS), (4) general knee pain (VAS), (5) pain at rest (VAS), (6) other composite pain scales, and (7) other single item measures. Disability: (1) WOMAC "function" subscale, (2) SF-36 "physical function" subscale, (3) SF-36 (Physical composite score), and (4) Other composite disability scores. Conclusions. As choosing the PRO most favourable for the intervention from individual trials can lead to biased estimates, using a prioritised list as developed in this study is recommended to reduce risk of biased selection of PROs in meta-analyses.
Original languageEnglish
JournalArthritis
Volume2012
Pages (from-to)136245
DOIs
Publication statusPublished - 2012

ID: 36796039