Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Schork, AJ, Won, H, Appadurai, V, Nudel, R, Gandal, M, Delaneau, O, Revsbech Christiansen, M, Hougaard, DM, Bækved-Hansen, M, Bybjerg-Grauholm, J, Giørtz Pedersen, M, Agerbo, E, Bøcker Pedersen, C, Neale, BM, Daly, MJ, Wray, NR, Nordentoft, M, Mors, O, Børglum, AD, Bo Mortensen, P, Buil, A, Thompson, WK, Geschwind, DH & Werge, T 2019, 'A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment' Nature Neuroscience. https://doi.org/10.1038/s41593-018-0320-0

APA

CBE

Schork AJ, Won H, Appadurai V, Nudel R, Gandal M, Delaneau O, Revsbech Christiansen M, Hougaard DM, Bækved-Hansen M, Bybjerg-Grauholm J, Giørtz Pedersen M, Agerbo E, Bøcker Pedersen C, Neale BM, Daly MJ, Wray NR, Nordentoft M, Mors O, Børglum AD, Bo Mortensen P, Buil A, Thompson WK, Geschwind DH, Werge T. 2019. A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. Nature Neuroscience. https://doi.org/10.1038/s41593-018-0320-0

MLA

Vancouver

Author

Schork, Andrew J ; Won, Hyejung ; Appadurai, Vivek ; Nudel, Ron ; Gandal, Mike ; Delaneau, Olivier ; Revsbech Christiansen, Malene ; Hougaard, David M ; Bækved-Hansen, Marie ; Bybjerg-Grauholm, Jonas ; Giørtz Pedersen, Marianne ; Agerbo, Esben ; Bøcker Pedersen, Carsten ; Neale, Benjamin M ; Daly, Mark J ; Wray, Naomi R ; Nordentoft, Merete ; Mors, Ole ; Børglum, Anders D ; Bo Mortensen, Preben ; Buil, Alfonso ; Thompson, Wesley K ; Geschwind, Daniel H ; Werge, Thomas. / A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. In: Nature Neuroscience. 2019.

Bibtex

@article{6efe210d55c2414bbeaaf4acf321d764,
title = "A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment",
abstract = "There is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not well characterized. Here we leverage the unique Integrative Psychiatric Research Consortium (iPSYCH) study, a nationally representative cohort ascertained through clinical psychiatric diagnoses indicated in Danish national health registers. We confirm previous reports of individual and cross-disorder single-nucleotide polymorphism heritability for major psychiatric disorders and perform a cross-disorder genome-wide association study. We identify four novel genome-wide significant loci encompassing variants predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex during mid-gestation. This epoch is supported by partitioning cross-disorder single-nucleotide polymorphism heritability, which is enriched at regulatory chromatin active during fetal neurodevelopment. These findings suggest that dysregulation of genes that direct neurodevelopment by common genetic variants may result in general liability for many later psychiatric outcomes.",
author = "Schork, {Andrew J} and Hyejung Won and Vivek Appadurai and Ron Nudel and Mike Gandal and Olivier Delaneau and {Revsbech Christiansen}, Malene and Hougaard, {David M} and Marie B{\ae}kved-Hansen and Jonas Bybjerg-Grauholm and {Gi{\o}rtz Pedersen}, Marianne and Esben Agerbo and {B{\o}cker Pedersen}, Carsten and Neale, {Benjamin M} and Daly, {Mark J} and Wray, {Naomi R} and Merete Nordentoft and Ole Mors and B{\o}rglum, {Anders D} and {Bo Mortensen}, Preben and Alfonso Buil and Thompson, {Wesley K} and Geschwind, {Daniel H} and Thomas Werge",
year = "2019",
month = "1",
day = "28",
doi = "10.1038/s41593-018-0320-0",
language = "English",
journal = "Reviews in the Neurosciences",
issn = "1097-6256",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment

AU - Schork, Andrew J

AU - Won, Hyejung

AU - Appadurai, Vivek

AU - Nudel, Ron

AU - Gandal, Mike

AU - Delaneau, Olivier

AU - Revsbech Christiansen, Malene

AU - Hougaard, David M

AU - Bækved-Hansen, Marie

AU - Bybjerg-Grauholm, Jonas

AU - Giørtz Pedersen, Marianne

AU - Agerbo, Esben

AU - Bøcker Pedersen, Carsten

AU - Neale, Benjamin M

AU - Daly, Mark J

AU - Wray, Naomi R

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Børglum, Anders D

AU - Bo Mortensen, Preben

AU - Buil, Alfonso

AU - Thompson, Wesley K

AU - Geschwind, Daniel H

AU - Werge, Thomas

PY - 2019/1/28

Y1 - 2019/1/28

N2 - There is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not well characterized. Here we leverage the unique Integrative Psychiatric Research Consortium (iPSYCH) study, a nationally representative cohort ascertained through clinical psychiatric diagnoses indicated in Danish national health registers. We confirm previous reports of individual and cross-disorder single-nucleotide polymorphism heritability for major psychiatric disorders and perform a cross-disorder genome-wide association study. We identify four novel genome-wide significant loci encompassing variants predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex during mid-gestation. This epoch is supported by partitioning cross-disorder single-nucleotide polymorphism heritability, which is enriched at regulatory chromatin active during fetal neurodevelopment. These findings suggest that dysregulation of genes that direct neurodevelopment by common genetic variants may result in general liability for many later psychiatric outcomes.

AB - There is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not well characterized. Here we leverage the unique Integrative Psychiatric Research Consortium (iPSYCH) study, a nationally representative cohort ascertained through clinical psychiatric diagnoses indicated in Danish national health registers. We confirm previous reports of individual and cross-disorder single-nucleotide polymorphism heritability for major psychiatric disorders and perform a cross-disorder genome-wide association study. We identify four novel genome-wide significant loci encompassing variants predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex during mid-gestation. This epoch is supported by partitioning cross-disorder single-nucleotide polymorphism heritability, which is enriched at regulatory chromatin active during fetal neurodevelopment. These findings suggest that dysregulation of genes that direct neurodevelopment by common genetic variants may result in general liability for many later psychiatric outcomes.

U2 - 10.1038/s41593-018-0320-0

DO - 10.1038/s41593-018-0320-0

M3 - Journal article

JO - Reviews in the Neurosciences

JF - Reviews in the Neurosciences

SN - 1097-6256

ER -

ID: 56470671