Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genome-wide association study implicates CHRNA2 in cannabis use disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

There is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not well characterized. Here we leverage the unique Integrative Psychiatric Research Consortium (iPSYCH) study, a nationally representative cohort ascertained through clinical psychiatric diagnoses indicated in Danish national health registers. We confirm previous reports of individual and cross-disorder single-nucleotide polymorphism heritability for major psychiatric disorders and perform a cross-disorder genome-wide association study. We identify four novel genome-wide significant loci encompassing variants predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex during mid-gestation. This epoch is supported by partitioning cross-disorder single-nucleotide polymorphism heritability, which is enriched at regulatory chromatin active during fetal neurodevelopment. These findings suggest that dysregulation of genes that direct neurodevelopment by common genetic variants may result in general liability for many later psychiatric outcomes.

Original languageEnglish
JournalNature Neuroscience
ISSN1097-6256
DOIs
Publication statusE-pub ahead of print - 28 Jan 2019

ID: 56470671