A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

Karen A Pooley; Stig E Bojesen; Maren Weischer; Sune F Nielsen; Deborah Thompson; Ali Amin Al Olama; Kyriaki Michailidou; Jonathan P Tyrer; Sara Benlloch; Judith Brown; Tina Audley; Robert Luben; K-T Khaw; David E Neal; Freddie C Hamdy; Jenny L Donovan; Zsofia Kote-Jarai; Caroline Baynes; Mitul Shah; Manjeet K Bolla; Qin Wang; Joe Dennis; Ed Dicks; Rongxi Yang; Anja Rudolph; Joellen Schildkraut; Jenny Chang-Claude; Barbara Burwinkel; Georgia Chenevix-Trench; Paul D P Pharoah; Andrew Berchuck; Rosalind A Eeles; Douglas F Easton; Alison M Dunning; Børge G Nordestgaard

doi:10.1093/hmg/ddt355

A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

Karen A Pooley, Stig E Bojesen, Maren Weischer, Sune F Nielsen, Deborah Thompson, Ali Amin Al Olama, Kyriaki Michailidou, Jonathan P Tyrer, Sara Benlloch, Judith Brown, Tina Audley, Robert Luben, K-T Khaw, David E Neal, Freddie C Hamdy, Jenny L Donovan, Zsofia Kote-Jarai, Caroline Baynes, Mitul Shah, Manjeet K BollaQin Wang, Joe Dennis, Ed Dicks, Rongxi Yang, Anja Rudolph, Joellen Schildkraut, Jenny Chang-Claude, Barbara Burwinkel, Georgia Chenevix-Trench, Paul D P Pharoah, Andrew Berchuck, Rosalind A Eeles, Douglas F Easton, Alison M Dunning, Børge G Nordestgaard

123 Citations (Scopus)

Abstract

Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the "iCOGS" custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend

Original language	English
Journal	Human Molecular Genetics
Volume	22
Issue number	24
Pages (from-to)	5056-64
Number of pages	9
ISSN	0964-6906
DOIs	https://doi.org/10.1093/hmg/ddt355
Publication status	Published - 15 Dec 2013

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Pooley, K. A., Bojesen, S. E., Weischer, M., Nielsen, S. F., Thompson, D., Amin Al Olama, A., Michailidou, K., Tyrer, J. P., Benlloch, S., Brown, J., Audley, T., Luben, R., Khaw, K.-T., Neal, D. E., Hamdy, F. C., Donovan, J. L., Kote-Jarai, Z., Baynes, C., Shah, M., ... Nordestgaard, B. G. (2013). A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Human Molecular Genetics, 22(24), 5056-64. https://doi.org/10.1093/hmg/ddt355

A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. / Pooley, Karen A; Bojesen, Stig E; Weischer, Maren et al.
In: Human Molecular Genetics, Vol. 22, No. 24, 15.12.2013, p. 5056-64.

Research output: Contribution to journal › Journal article › Research › peer-review

Pooley, KA, Bojesen, SE, Weischer, M, Nielsen, SF, Thompson, D, Amin Al Olama, A, Michailidou, K, Tyrer, JP, Benlloch, S, Brown, J, Audley, T, Luben, R, Khaw, K-T, Neal, DE, Hamdy, FC, Donovan, JL, Kote-Jarai, Z, Baynes, C, Shah, M, Bolla, MK, Wang, Q, Dennis, J, Dicks, E, Yang, R, Rudolph, A, Schildkraut, J, Chang-Claude, J, Burwinkel, B, Chenevix-Trench, G, Pharoah, PDP, Berchuck, A, Eeles, RA, Easton, DF, Dunning, AM & Nordestgaard, BG 2013, 'A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk', Human Molecular Genetics, vol. 22, no. 24, pp. 5056-64. https://doi.org/10.1093/hmg/ddt355

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abstract = "Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the {"}iCOGS{"} custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend ",

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AU - Bojesen, Stig E

AU - Weischer, Maren

AU - Nielsen, Sune F

AU - Thompson, Deborah

AU - Amin Al Olama, Ali

AU - Michailidou, Kyriaki

AU - Tyrer, Jonathan P

AU - Benlloch, Sara

AU - Brown, Judith

AU - Audley, Tina

AU - Luben, Robert

AU - Khaw, K-T

AU - Neal, David E

AU - Hamdy, Freddie C

AU - Donovan, Jenny L

AU - Kote-Jarai, Zsofia

AU - Baynes, Caroline

AU - Shah, Mitul

AU - Bolla, Manjeet K

AU - Wang, Qin

AU - Dennis, Joe

AU - Dicks, Ed

AU - Yang, Rongxi

AU - Rudolph, Anja

AU - Schildkraut, Joellen

AU - Chang-Claude, Jenny

AU - Burwinkel, Barbara

AU - Chenevix-Trench, Georgia

AU - Pharoah, Paul D P

AU - Berchuck, Andrew

AU - Eeles, Rosalind A

AU - Easton, Douglas F

AU - Dunning, Alison M

AU - Nordestgaard, Børge G

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AB - Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the "iCOGS" custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend

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A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

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