A firstborn boy is suggestive of a strong prognostic factor in secondary recurrent miscarriage: a confirmatory study

Henriette Svarre Nielsen; Anne-Marie Nybo Andersen; Astrid Marie Kolte; Ole Bjarne Christiansen

doi:10.1016/j.fertnstert.2007.04.029

A firstborn boy is suggestive of a strong prognostic factor in secondary recurrent miscarriage: a confirmatory study

Henriette Svarre Nielsen, Anne-Marie Nybo Andersen, Astrid Marie Kolte, Ole Bjarne Christiansen

48 Citations (Scopus)

Abstract

OBJECTIVE: To test our previously generated hypothesis that women with secondary recurrent miscarriages with a firstborn boy have a poorer pregnancy prognosis than those with a firstborn girl.

DESIGN: A study of a retrospective and a prospective cohort.

SETTING: The Danish recurrent miscarriage clinic.

PATIENT(S): Two cohorts of 175 and 130 consecutive patients with unexplained secondary recurrent miscarriage referred from 1986 to 1999 (cohort 1) and 2000 to 2005 (cohort 2), respectively.

MAIN OUTCOME MEASURE(S): The odds ratio (OR) for a live birth in the first pregnancy after referral in those with a firstborn boy compared with a firstborn girl in each of the two cohorts. The corresponding OR for a live birth adjusted for relevant prognostic variables in the combined group of patients.

RESULT(S): The crude ORs for a live birth in those with a firstborn boy compared with a firstborn girl were very similar in cohorts 1 and 2 (OR = 0.35, 0.33). In the adjusted analysis only two of five included variables significantly predicted live birth: a firstborn boy and the number of previous miscarriages.

CONCLUSION(S): Male sex of the firstborn child is a strong negative prognostic factor in women with secondary recurrent miscarriage. A possible explanation is an abnormal maternal immune response against male-specific minor histocompatibility (HY) antigens.

Original language	English
Journal	Fertility and Sterility
Volume	89
Issue number	4
Pages (from-to)	907-11
Number of pages	5
ISSN	0015-0282
DOIs	https://doi.org/10.1016/j.fertnstert.2007.04.029
Publication status	Published - Apr 2008
Externally published	Yes

Keywords

Abortion, Habitual
Adult
Female
H-Y Antigen
Humans
Infant, Newborn
Live Birth
Logistic Models
Male
Odds Ratio
Pregnancy
Prognosis
Prospective Studies
Retrospective Studies
Risk Factors
Sex Factors
Sex Ratio

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10.1016/j.fertnstert.2007.04.029

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title = "A firstborn boy is suggestive of a strong prognostic factor in secondary recurrent miscarriage: a confirmatory study",

abstract = "OBJECTIVE: To test our previously generated hypothesis that women with secondary recurrent miscarriages with a firstborn boy have a poorer pregnancy prognosis than those with a firstborn girl.DESIGN: A study of a retrospective and a prospective cohort.SETTING: The Danish recurrent miscarriage clinic.PATIENT(S): Two cohorts of 175 and 130 consecutive patients with unexplained secondary recurrent miscarriage referred from 1986 to 1999 (cohort 1) and 2000 to 2005 (cohort 2), respectively.MAIN OUTCOME MEASURE(S): The odds ratio (OR) for a live birth in the first pregnancy after referral in those with a firstborn boy compared with a firstborn girl in each of the two cohorts. The corresponding OR for a live birth adjusted for relevant prognostic variables in the combined group of patients.RESULT(S): The crude ORs for a live birth in those with a firstborn boy compared with a firstborn girl were very similar in cohorts 1 and 2 (OR = 0.35, 0.33). In the adjusted analysis only two of five included variables significantly predicted live birth: a firstborn boy and the number of previous miscarriages.CONCLUSION(S): Male sex of the firstborn child is a strong negative prognostic factor in women with secondary recurrent miscarriage. A possible explanation is an abnormal maternal immune response against male-specific minor histocompatibility (HY) antigens.",

keywords = "Abortion, Habitual, Adult, Female, H-Y Antigen, Humans, Infant, Newborn, Live Birth, Logistic Models, Male, Odds Ratio, Pregnancy, Prognosis, Prospective Studies, Retrospective Studies, Risk Factors, Sex Factors, Sex Ratio",

author = "Nielsen, \{Henriette Svarre\} and Andersen, \{Anne-Marie Nybo\} and Kolte, \{Astrid Marie\} and Christiansen, \{Ole Bjarne\}",

year = "2008",

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doi = "10.1016/j.fertnstert.2007.04.029",

language = "English",

volume = "89",

pages = "907--11",

journal = "Fertility and Sterility",

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T1 - A firstborn boy is suggestive of a strong prognostic factor in secondary recurrent miscarriage

T2 - a confirmatory study

AU - Nielsen, Henriette Svarre

AU - Andersen, Anne-Marie Nybo

AU - Kolte, Astrid Marie

AU - Christiansen, Ole Bjarne

PY - 2008/4

Y1 - 2008/4

N2 - OBJECTIVE: To test our previously generated hypothesis that women with secondary recurrent miscarriages with a firstborn boy have a poorer pregnancy prognosis than those with a firstborn girl.DESIGN: A study of a retrospective and a prospective cohort.SETTING: The Danish recurrent miscarriage clinic.PATIENT(S): Two cohorts of 175 and 130 consecutive patients with unexplained secondary recurrent miscarriage referred from 1986 to 1999 (cohort 1) and 2000 to 2005 (cohort 2), respectively.MAIN OUTCOME MEASURE(S): The odds ratio (OR) for a live birth in the first pregnancy after referral in those with a firstborn boy compared with a firstborn girl in each of the two cohorts. The corresponding OR for a live birth adjusted for relevant prognostic variables in the combined group of patients.RESULT(S): The crude ORs for a live birth in those with a firstborn boy compared with a firstborn girl were very similar in cohorts 1 and 2 (OR = 0.35, 0.33). In the adjusted analysis only two of five included variables significantly predicted live birth: a firstborn boy and the number of previous miscarriages.CONCLUSION(S): Male sex of the firstborn child is a strong negative prognostic factor in women with secondary recurrent miscarriage. A possible explanation is an abnormal maternal immune response against male-specific minor histocompatibility (HY) antigens.

AB - OBJECTIVE: To test our previously generated hypothesis that women with secondary recurrent miscarriages with a firstborn boy have a poorer pregnancy prognosis than those with a firstborn girl.DESIGN: A study of a retrospective and a prospective cohort.SETTING: The Danish recurrent miscarriage clinic.PATIENT(S): Two cohorts of 175 and 130 consecutive patients with unexplained secondary recurrent miscarriage referred from 1986 to 1999 (cohort 1) and 2000 to 2005 (cohort 2), respectively.MAIN OUTCOME MEASURE(S): The odds ratio (OR) for a live birth in the first pregnancy after referral in those with a firstborn boy compared with a firstborn girl in each of the two cohorts. The corresponding OR for a live birth adjusted for relevant prognostic variables in the combined group of patients.RESULT(S): The crude ORs for a live birth in those with a firstborn boy compared with a firstborn girl were very similar in cohorts 1 and 2 (OR = 0.35, 0.33). In the adjusted analysis only two of five included variables significantly predicted live birth: a firstborn boy and the number of previous miscarriages.CONCLUSION(S): Male sex of the firstborn child is a strong negative prognostic factor in women with secondary recurrent miscarriage. A possible explanation is an abnormal maternal immune response against male-specific minor histocompatibility (HY) antigens.

KW - Abortion, Habitual

KW - Adult

KW - Female

KW - H-Y Antigen

KW - Humans

KW - Infant, Newborn

KW - Live Birth

KW - Logistic Models

KW - Male

KW - Odds Ratio

KW - Pregnancy

KW - Prognosis

KW - Prospective Studies

KW - Retrospective Studies

KW - Risk Factors

KW - Sex Factors

KW - Sex Ratio

UR - https://www.scopus.com/pages/publications/41749097652

U2 - 10.1016/j.fertnstert.2007.04.029

DO - 10.1016/j.fertnstert.2007.04.029

M3 - Journal article

C2 - 18222440

SN - 0015-0282

VL - 89

SP - 907

EP - 911

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

A firstborn boy is suggestive of a strong prognostic factor in secondary recurrent miscarriage: a confirmatory study

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Keywords

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