Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A Danish population-based case series of patients with liver cirrhosis and coronavirus disease 2019

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Fecal microbiota transplantation in hepatic encephalopathy: a systematic review

    Research output: Contribution to journalReviewpeer-review

  2. eHealth: Disease activity measures are related to the faecal gut microbiota in adult patients with ulcerative colitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Fecal microbiota transplantation in hepatic encephalopathy: a systematic review

    Research output: Contribution to journalReviewpeer-review

  2. Postprandial Increase in Mesenteric Blood Flow is Attenuated in Parkinson's Disease: A Dynamic PC-MRI Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Editorial: non-selective beta blockers-in and out of circulation

    Research output: Contribution to journalEditorialpeer-review

View graph of relations

Objectives: Coronavirus disease 2019 (COVID-19) is an ongoing major health emergency, but its occurrence and clinical impact on patients withliver cirrhosis is unknown. Therefore, we conducted a population-based study of 2.6 million Danish citizens investigating the occurrence and impact of COVID-19 in patients with liver cirrhosis. Materials and methods: A prospective population-based cohort study was conducted in the Capital Region of Denmark and Region Zealand in the study period between 1 March 2020 up until 31 May 2020, with the only eligibility criteria being a reverse-transcriptase polymerase chain reaction for presence of viral genomic material confirming COVID-19. The patients were subsequently stratified according to presence of pre-existing liver cirrhosis. Results: Among 575,935 individuals tested, 1713 patients had a diagnosis of cirrhosis. COVID-19 occurredsignificantly lessamongpatients with cirrhosis (n = 15; 0.9%, p <.01) compared with the population without cirrhosis (n = 10,593; 1.8%). However, a large proportion (n = 6;40.0%) required a COVID-19 related hospitalization which was correlated with higher values of alanine aminotransferase (p <.01) and lactate dehydrogenase (p =.04). In addition, one-in-three (n = 2; 13.3%) required intensive therapy. Four patients died (26.7%) and mortality was associated with higher MELD scores, co-existing type 2 diabetes, and bacterial superinfections. Conclusion: In conclusion, patientswith cirrhosis may have a lower risk of COVID-19; but a higher risk of complications hereto and mortality.

Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume56
Issue number4
Pages (from-to)453-457
Number of pages5
ISSN0036-5521
DOIs
Publication statusPublished - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • COVID-19, acute-on-chronic liver failure, coronavirus disease 2019, disease course, epidemiology, infectious diseases, liver cirrhosis, mortality, population-based, superinfections

ID: 62309832